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ProteomicsCINC-2 and miR-199a-5p in exosomes secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration
Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat livers treated with retrorsine and with 70% partial hepatectomy (PH). We previously reported that transplantation of Thy1+ cells derived from D-galactosamine-treated livers promotes ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-07 | PXD039384 | Pride
Thy1 Il17rb Shpcs Kupffer cells Sinusoidal endothelial cells Lc-ms/ms 
TranscriptomicsSequencing of microRNA in spermatogonial stem cell enriched cell populations.
MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems where their functions include the regulation of self-renewal, cellular differentiation, proliferation, and apoptosis. However, the functional importance of individual miRs in controlling spermatogoni...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-29613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse gonocytes isolated from 2 dpp mouse testes by THY1+ MACS sorting and treated with retinoic acid
to investigate the RA regulated genes in 2 dpp thy1+ gonocytes Experiment Overall Design: gonocytes were isolated from 2 dpp mouse testes by THY1+ MACS sorting and cultured without serum, growth factors and feeder cells for 8hr, with either vehicle ethanol or RA (100 nM). Two control and two RA trea...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9521 | biostudies-arrayexpress
TranscriptomicsAnalysis of striatal transcriptome in transgenic mice overexpressing human wild-type alpha-synuclein
Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson’s disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other syn...
ORGANISM(S): Mus musculus 
2012-02-11 | E-GEOD-35723 | biostudies-arrayexpress
TranscriptomicsExpression of rat hepatocytic progenitor cells with and without hepatic Thy1-positive cells in retrorsine/partial hepatectomy treated rats models.
We found that the transplantation of Thy1+ cells transiently increased the liver mass by expanding resident small hepatocy-like progenitor cells(SHPCs). We used microarrays to detail the gene expression of receptors of growth factors of SHPCs clusters with and without Thy1+ cells transplantation. SH...
ORGANISM(S): Rattus norvegicus 
2016-08-14 | E-GEOD-85577 | biostudies-arrayexpress
TranscriptomicsmicroRNA profile analysis of sorted cells during different reprogramming stages
Mouse embryonic fibroblasts were reprogrammed using Oct4, Sox2, Klf4 and cMyc genes. At day 5, cells were sorted as Thy1 positive and Thy1 negative populations. microRNA expression profile from Thy1+ and Thy1- cells was compared with original MEFs (D0) to identify significantly changed microRNAs dur...
ORGANISM(S): Mus musculus 
2015-09-12 | E-MTAB-2932 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of germ cell RA signaling mutant and control THY1+ spermatogonia Transcriptomes
Purpose: The goal of this sequencing is to investigate alterations in gene expression that result from impaired retinoid signaling compared with control, and how the RA signaling controls spermatogonia differentiation Methods: THY1+ spermatogonia mRNA profiles of 4-day-old control and germ cell spe...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-79863 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of the SSC-Enriched Thy1+ and SSC-Depleted Thy1- Fractions of Prepubertal Mouse Testes
Self-renewal and differentiation of spermatogonial stem cells (SSCs) provides the foundation for testis homeostasis, yet mechanisms that control their functions in mammals are poorly defined. We used microarray transcript profiling to identify specific genes whose expression are augmented in the SSC...
ORGANISM(S): Mus musculus 
2008-12-30 | GSE14222 | GEO
GenomicsMus musculus strain:B6.Cg-Tg(Thy1-YFP)16Jrs/J | breed:Thy1-YFP transgenic mice
Mus musculus strain:B6.Cg-Tg(Thy1-YFP)16Jrs/J | breed:Thy1-YFP transgenic mice Raw sequence reads
PRJNA1158961 | ENA
UnknownNeuronal THY1 Signaling Maintains Astrocytes in a Quiescent State.
Not available
S-EPMC12666997 | biostudies-literature
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