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ProteomicsCharacterisation of the protein cargo of murine plasma microparticles released during experimental cerebral malaria
Cerebral malaria (CM) is a severe complication of a Plasmodium falciparum infection and is still responsible for a high number of deaths and long term disabilities in children in sub-Saharan Africa. The pathogenesis of this syndrome remains incompletely understood but a number of mechanisms and effe...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-13 | PXD003772 | Pride
Qexactive orbitrap Protein cargo Tandem mass tag (tmt) Microparticles Experimental cerebral malaria 
ProteomicsCerebrospinal Fluid-Derived Microvesicles from Sleeping Sickness Patients Alter Protein Expression in Human Astrocytes
Human African trypanosomiasis (HAT) caused by the extracellular protozoon Trypanosoma brucei, is a neglected tropical disease affecting the poorest communities in sub-Saharan Africa. HAT progresses from a hemolymphatic first stage (S1) to a meningo-encephalitic late stage (S2) when parasites reach t...
ORGANISM(S): Homo sapiens (Human) 
2019-10-28 | PXD014945 | Pride
Astrocytes Microvesicles Cerebrospinal fluid Dia-ms Human african trypanosomiasis 
ProteomicsQuantitative comparison of CSF proteins from T. b. gambiense and T. b. rhodesiense HAT patients
The host central nervous system (CNS) response to infection with Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense parasites, the causing agent of human African trypanosomiasis (HAT), is a poorly explored area. The two parasites are responsible for respectively a chronic and an acute form of...
ORGANISM(S): Homo sapiens (Human) 
2015-01-23 | PXD001082 | Pride
Tandem mass tag (tmt) Human cerebrospinal fluid Esi ltq orbitrap Human african trypanosomiasis 
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