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MetabolomicsUntapped enzymatic potential: dehalogenase- and peroxidase-driven PVC degradation by gene carriers in Tibetan plateau pikas

Wide contamination of MPs including polyvinyl chloride (PVC) has been reported in remote regions such as Qinghai-Tibet Plateau (QTP). Microbial degradation of plastics is frequently coupled with lignocellulose-degrading enzymatic machinery. Given its status as a widespread biological sampler in Q...

2026-02-20 | MTBLS13916 | MetaboLights
ProteomicsDairying supported prehistoric occupation of the highland Tibetan Plateau
The extreme environments of the Tibetan Plateau offer significant challenges to human survival, demanding novel adaptations. While the role of biological and agricultural adaptations in enabling early human colonization of the plateau has been widely discussed, the contribution of pastoralism is les...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD028538 | Pride
Tibetan plateau Paleoproteomics High-altitude adaptation Dairy pastoralism 
TranscriptomicsLocust flight muscle: Tibetan Plateau population vs. North China Plain population
Background: Responses to hypoxia have been investigated in many species; however, comparative study between conspecific geographical populations in different altitude regions is rare, especially for invertebrates . The migratory locust, Locusta migratoria, is widely distributed both on high-altitude...
ORGANISM(S): Locusta migratoria 
2013-12-24 | E-GEOD-43327 | biostudies-arrayexpress
MetabolomicsInitial exploration of the health effects on Qinghai-Tibetan Plateau yaks following short-term exposure to polystyrene microplastics: analysis of rumen microbiota, host metabolism, antioxidant function and inflammatory responses.

Abstract: Microplastics (MPs) are omnipresent in the environment, including the Qinghai-Tibet Plateau. Previous research on MPs has primarily focused on aquatic species and rodents, with little known about their impact on yaks. This study introduced yak as an animal model, employing a combin...

2026-01-17 | MTBLS13707 | MetaboLights
MetabolomicsInitial exploration of the health effects on Qinghai-Tibetan Plateau yaks following short-term exposure to polystyrene microplastics: analysis of rumen microbiota, host metabolism, antioxidant function and inflammatory responses

Microplastics (MPs) are omnipresent in the environment, including the Qinghai-Tibet Plateau. Previous research on MPs has primarily focused on aquatic species and rodents, with little known about their impact on yaks. This study introduced yak as an animal model, employing a combined analysis of ...

2026-01-17 | MTBLS13704 | MetaboLights
MetabolomicsRevealing the Adaptive Metabolic Differences of Different Sheep Breeds in Plateau Areas Based on the Gut-Heart Axis

Gut microbiota plays a significant role in maintaining the homeostasis of the gut internal environment, and the volatile fatty acids (VFAs) produced by it are the main source of energy utilization for the host. The heart, as a key metabolic organ of the body, its energy metabolism efficiency dire...

2025-09-11 | MTBLS12982 | MetaboLights
MetabolomicsGlycosylation-mediated detoxification of zearalenone by the Tibetan yeast Hannaella zeae: Multi-omics insights into its dual-function mechanism

This study investigated the detoxification of zearalenone (ZEN) by the Tibetan Plateau yeast Hannaella zeae via untargeted LC-MS/MS-based metabolomics. H. zeae was cultured in NYDB medium with ZEN supplementation, and samples were harvested after 36 h of incubation for metabolomic analysis. The c...

2026-08-20 | MTBLS15233 | MetaboLights
TranscriptomicsGene Expression Profiling of High Altitude Polycythemia in Han Chinese migrated to Qinghai-Tibetan Plateau
Long term-exposed to high altitude, the increased numbers of red blood cells tend to stabilize to a certain extend in most people, but someone will occur over-increasing in number of red blood cells, which cause a serious of clinical symptoms and signs, and this is high altitude polycythemia. EPO-EP...
ORGANISM(S): Homo sapiens 
2014-06-15 | E-GEOD-29977 | biostudies-arrayexpress
GenomicsTibetan Plateau wetland metagenome
Tibetan Plateau wetland metagenome Raw sequence reads
PRJNA744994 | ENA
ProteomicsA late Middle Pleistocene Denisovan mandible from the Tibetan Plateau
A dentine sample from a previously unknown hominin specimen deriving from the Tibetan Plateau was analyzed using LC-MS/MS in order to characterize its proteome, protein damage characteristics, and phylogenetic affinities to known Late Pleistocene hominin clades (humans, Neanderthals, Denisovans).
ORGANISM(S): Homo 
2019-05-08 | PXD011377 | Pride
Zooms Middle pleistocene Hominin Palaeoproteomics 
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