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ProteomicsRevealing the transitory and local effect of the demethylation agent zebularine on plant development and proteome dynamics of Salix purpurea
DNA methylation plays major roles in the epigenetic regulation of gene expression, transposon and transcriptional silencing, and DNA repair, with implications in developmental processes and phenotypic plasticity. Relevantly for arboreal species, DNA methylation constitute a regulative layer in cell ...
ORGANISM(S): Sarracenia purpurea subsp. purpurea 
2024-01-08 | PXD045653 | Pride
Proteomics Cell wall Cytidine analogue Dna methylation Purple willow 
ProteomicsECM composition dictates the mode of cell competition and competence for tumor initiation
The skin epidermis is constantly renewed throughout life1,2. Disruption of the balance between renewal and differentiation can lead to uncontrolled growth and tumour initiation3. Basal cell carcinoma (BCC) is the most frequent cancer in human4,5. Cell competition, the elimination of less fit cells b...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-27 | PXD041644 | Pride
Ecm Bcc Live imaging Tumor initiation Cell competition 
ProteomicsNaa80 acetylates the actin N-terminus impacting the actin cytoskeleton and cell motility
Eukaryotic actins undergo several post-translational modifications during their maturation to enable a fully functional cytoskeletal network. A unique N-terminal processing is conserved in the animal kingdom and includes the removal of the first one or two amino acids as well as N-terminal acetylati...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006856 | Pride
N-terminal acetylation Nat Actin Human 
ProteomicsNOVEL ROLE OF FATTY ACID SYNTHASE IN ANGIOGENESIS THROUGH MODULATION OF LYSINE MALONYLATION OF MTOR
The role of fatty acid synthesis (FAS) in endothelial cells (ECs) remains incompletely characterized. In this project, we found that silencing of fatty acid synthase (FASN) impedes vessel sprouting by reducing EC proliferation. Moreover, loss of FASN in ECs impaired angiogenesis in vivo, and FASN bl...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD006503 | Pride
Protein malonylation Fatty acid synthesis Endothelial cell metabolism 
ProteomicsRecombinant extracellular vesicles as a biological reference material
Recent years have seen a tremendous increase in the study of extracellular vesicles (EV) geared towards biological understanding, diagnostics and therapy. The interpretation of EV data however remains challenging owing to the complexity of biofluids and the technical variability that are introduced ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD010269 | Pride
Vlps Proteomics Mass spectrometry Revs Hek293t cells 
ProteomicsA COFRADIC protocol to study protein ubiquitination
We here apply the COmbined FRActional DIagonal Chromatography (COFRADIC) technology to enrich for ubiquitinated peptides and identify sites of ubiquitination by mass spectrometry. Our technology bypasses the need to ectopically overexpress tagged variants of ubiquitin and the use of sequence-biased ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080780 | MassIVE
ProteomicsFerroptosis-armed dendritic cell vaccines for glioma immunotherapy
The type of cell death has proven to play a crucial role in cancer immunotherapy efficacy. Immunogenic cell death (ICD) enhances tumor adjuvanticity and antigenicity by releasing danger signals and altering the immune peptidome. The immunogenicity of ferroptosis, an iron-dependent form of cell death...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-17 | PXD060116 | Pride
Glioblastoma Immunogenic cell death (icd) Antigenicity Mouse Ferroptosis Gl261 
ProteomicsAspergillus fumigatus spore proteases alter the respiratory mucosa architecture and facilitate equine herpesvirus 1 infection
The interaction between Aspergillus fumigatus (Af) spores and the respiratory epithelium, as well as its impact on the epithelial barrier function, remain largely unknown. The respiratory epithelial barrier protects the respiratory epithelium against viral infections. However, it can be compromised ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2024-08-14 | PXD053508 | Pride
Proteases Aspergillus fumigatus spores Lc-ms/ms 
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