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TranscriptomicsTHP1 derived macrophage and foam cell gene expression in presence and absence of T0901317 and RNAi analyses of LXRa/b
To assess the LXRa dependent regulatory pathways in macrophages and foam cells we treated our two, THP1 derived native and LXR-knockdown cell models either with T0901317 or vehicle control (DMSO).
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1106 | biostudies-arrayexpress
UnknownAltered DNA Methylation Profiles in SF3B1 Mutated CLL Patients.
Not available
S-EPMC8431484 | biostudies-literature
GenomicsRegulation of the KEAP1/NRF2 oxidative stress response pathway by BRD4 in prostate and colorectal cancer
To identify genes regulated by BRD4 and to provide insight into new mechanisms de-regulated by BRD4, such as the response to oxidative stress, we integrated BRD4-binding regions with BRD4 gene expression data. For this analysis we performed BRD4 chromatin immunoprecipitation experiments and BRD4 kn...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-50491 | biostudies-arrayexpress
TranscriptomicsThe bromodomain protein BRD4 regulates splicing during heat shock
During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress
UnknownManagement of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity.
Not available
S-EPMC9350006 | biostudies-literature
UnknownReconstruction of a gene regulatory network of the induced systemic resistance defense response in Arabidopsis using boolean networks.
Not available
S-EPMC7157984 | biostudies-literature
UnknownSynthetic high-density lipoprotein nanoconjugate targets neuroblastoma stem cells, blocking migration and self-renewal.
Not available
S-EPMC6814450 | biostudies-literature
UnknownProbabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections.
Not available
S-EPMC7286851 | biostudies-literature
ProteomicsCell autonomous requirement of Neurofibrimin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis
Background Neurofibromatosis type 1 (NF1) is a multi-organ disease caused by mutations in Neurofibromin (NF1). Amongst other features, NF1 patients frequently show reduced muscle mass and strength, impairing patients’ mobility and increasing the risk of fall. The role of Nf1 in muscle and the cause ...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-26 | PXD017958 | Pride
Myopathy Muscle atrophy Neurofibromatosis Muscle metabolism Muscle fiber type 
UnknownThe cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5' splice site that impacts splicing regulation in Q157R patients.
Not available
S-EPMC5689001 | biostudies-literature
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