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MetabolomicsAbsence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis
Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how...
2024-10-31 | MTBLS11505 | MetaboLights
MetabolomicsCRISPR-Cas9 knockout of WS1A/WS1B alleviates postharvest green vein defect via tissue-specific chloroplast degradation in flue-cured tobacco
This dataset contains tissue-resolved untargeted metabolome data from flue-cured tobacco cultivar Honghuadajinyuan (wild-type) and transgene-free ws1 mutants generated by CRISPR-Cas9 knockout of homeologous WS1A/WS1B. Multiple tobacco tissues were profiled to capture metabolite alterations triggered...
2026-10-10 | MTBLS15979 | MetaboLights
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Brain tissue metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-12-05 | MTBLS4894 | MetaboLights
TranscriptomicsFKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance.
Glucocorticoid excess is linked to central obesity, adipose tissue insulin resistance and type 2 diabetes mellitus. The aim of our study was to investigate the effects of dexamethasone on gene expression in human subcutaneous and omental adipose tissue, in order to identify potential novel mechanism...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-42902 | biostudies-arrayexpress
ProteomicsTissue and organ matrix arrays for high throughput screening and systems analysis of cell function
Cell and protein arrays have demonstrated remarkable utility in the high-throughput evaluation of biological responses; however, they lack the complexity of native tissue and organs and cannot replicate the environment of mature normal or diseased tissues. Here, we describe the development of tissue...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2015-09-28 | PXD002571 | Pride
Tissue array Matrix Organ array Ecm 
TranscriptomicsHeterogeneous genetic profiles in soft tissue myoepitheliomas
Myoepithelioma, mixed tumor and parachordoma are rare soft tissue tumors thought to represent different morphologic variants of the same family of tumors, hereafter referred to as MMP tumors. The genetic basis of these neoplasms is poorly investigated. However, they morphologically resemble mixed tu...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10266 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for esophageal squamous cell carcinoma (ESCC) samples
We demonstrate that blood and esophageal tissues shared similar DNA methylation patterns within the same individual,suggesting an influence of genetic background on DNA methylation. Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However,...
ORGANISM(S): Homo sapiens 
2010-08-02 | E-GEOD-20123 | biostudies-arrayexpress
TranscriptomicsSubtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
This SuperSeries is composed of the following subset Series: GSE21122: Whole-transcript expression data for soft-tissue sarcoma tumors and control normal fat specimens GSE21123: Affymetrix SNP array data for soft tissue sarcoma samples Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21124 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for soft tissue sarcoma samples
Soft tissue sarcomas are aggressive mesenchymal cancers that affect more than 10,600 new patients per year in the US, about 40% of whom will die of their disease. Soft tissue sarcomas exhibit remarkable histologic diversity, with more than 50 recognized subtypes, but our knowledge of their genomic a...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21123 | biostudies-arrayexpress
TranscriptomicsHigh Resolution Copy Number Analysis of Paraffin Embedded Archival Tissue Using SNP BeadArrays
High density SNP microarrays provide insight into the genomic events that occur in diseases like cancer by their capability to measure both LOH and genomic copy numbers. Where currently available methods are restricted to the use of fresh frozen tissue, we now describe the design and validation of c...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5347 | biostudies-arrayexpress
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