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ProteomicsDietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world’s longest selection experiments for high body mass and was previously...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD019030 | Pride
Acetylome Shotgun proteomics Titan mouse model Metabolic syndrome 
GenomicsDietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
PRJNA631036 | ENA
TranscriptomicsDietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world’s longest selection experiments for high body mass and was previously...
ORGANISM(S): Mus musculus 
2022-05-01 | GSE150073 | GEO
UnknownDietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.
Not available
S-EPMC9065075 | biostudies-literature
UnknownTitan mice as a model to test interventions that attenuate frailty and increase longevity.
Not available
S-EPMC11226689 | biostudies-literature
GenomicsThe transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity
The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity
PRJNA641574 | ENA
TranscriptomicsEstrogen signaling and the Metabolic Syndrome: Targeting the hepatic ERalpha action
We have previously shown that total estrogen receptor alpha (ERalpha knockout (KO) mice exhibit hepatic insulin resistance. To investigate the contribution of hepatic ERalpha action for the observed phenotype, we established a liver-selective ERalphaKO mouse model, LERKO. We demonstrate that LERKO m...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-36514 | biostudies-arrayexpress
GenomicsThe transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity
We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcine...
ORGANISM(S): Cryptococcus neoformans 
2021-02-16 | GSE153134 | GEO
TranscriptomicsThe transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity (RNA-Seq)
We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcine...
ORGANISM(S): Cryptococcus neoformans 
2021-02-16 | GSE162851 | GEO
TranscriptomicsMouse Models of Alveolar/Embryonal Rhabdomyosarcoma & Spindle Cell Sarcomas
A series of conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma were generated and validated for relavence to corresponding human cancers. Conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-22520 | biostudies-arrayexpress
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