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ProteomicsFinding TMEM55B interactors and ubiquitination sites
Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms. Here we find the interactors for TMEM55B and also checked ubiquitination o...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD043609 | Pride
Tmem55b ms 
ProteomicsFinding TMEM55B phoshporylation site
Lysosomes have emerged as critical regulators of cellular homeostasis. Here we show that the lysosomal protein TMEM55B contributes to restore cellular homeostasis in response to oxidative stress by three different mechanisms. Here we find the interactors for TMEM55B and also checked ubiquitination o...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD046394 | Pride
Tmem55b ms 
ProteomicsStructural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
Inherited mutations in VPS35 and the kinase LRRK2 lead to hyperphosphorylation of Rab GTPases and promote the formation of phospho-Rab signalling complexes. A subset of RH2 domain-containing proteins from the RILP-homology family, including RILP, RILPL1, RILPL2, JIP3, and JIP4 are Rab effectors that...
ORGANISM(S): Homo sapiens (Human) 
2025-11-30 | PXD067414 | Pride
Lysosome Lrrk2 Tmem55b Parkinson's disease Structure 
ProteomicsParkinson’s VPS35[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
The Parkinson’s VPS35[D620N] mutation causes lysosome dysfunction enhancing LRRK2 kinase activity. We find the VPS35[D620N] mutation alters expression of ~350 lysosomal proteins and stimulates LRRK2 recruitment and phosphorylation of Rab proteins at the lysosome. This recruits the phosphoRab effecto...
ORGANISM(S): Homo sapiens (Human) 
2023-11-08 | PXD045671 | Pride
Parkinson's disease Lrrk2 Lysosome Proteomics 
ProteomicsParkinson’s VPS35[D620N] retromer lysosomal dysfunction induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
The D620N VPS35 mutation disrupts retrograde endosome to Golgi retromer Trafficking. Thus causes lysosome dysfunction, enhances LRRK2 kinase activity and leads to Parkinson’s disease. We employed a LysoTag immunoprecipitation approach to assess how this impacts lysosomes using quantitative proteomic...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD042502 | Pride
Parinson's disease  lysosomal proteins  lrrk2  rilpl1  tmem55b 
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