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ProteomicsQuantitative proteomic analysis identifies TUBB2A as a novel protein biomarker for prediction of distant metastatic breast cancer
Metastasis of breast cancer to other distant organs is fatal to patients. However, few studies have revealed biomarkers associated with distant metastatic breast cancer. Furthermore, the inability of current biomarkers such as HER2, ER and PR, in accurately differentiating between distant metastatic...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD016061 | Pride
Formalin-fixed paraffin-embedded (ffpe) tissue Distant metastatic breast cancer Tandem mass tag (tmt) Quantitative proteomics Biomarkers 
ProteomicsQuantitative Proteomics implicates CD44 in proliferation of breast cancer cell
CD44 is a transmembrane glycoprotein playing a key role in cel adhesion to the extracellular matrix. CD44 expression is upregulated in various cancer cells and recognized as a molecular marker for tumor-initiating cancer cells. However, the intricate correlation between CD44 and underlying biologica...
ORGANISM(S): Homo sapiens (Human) 
2021-06-10 | PXD015171 | Pride
Human Cd44 Breast cancer Tmt 
ProteomicsLowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach
Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation (IP) of phosphotyrosine (pY) peptides prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to profile kinase substrates. A typical protocol requests ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD018952 | Pride
Signaling Tmt Cancer Calibrator Tyrosine phosphorylation 
ProteomicsBreast cancer exosome protein profiling using TMT quantitation and SVM analysis
Exosomes are microvesicles of endocytic origin constitutively released by multiple cell types into the extracellular environment. With evidence that exosomes can be detected in the blood of patients with various onco-malignancies, the development of a platform that uses exosomes as a diagnostic tool...
ORGANISM(S): Homo sapiens (Human) 
2015-10-02 | PXD002053 | Pride
Human Exosomes Tmt quantitation Breact cancer 
ProteomicsTMT 10-plex based quantitative proteomic analysis of drug resistant breast cancer cell lines
Breast cancer accounts for roughly 30% of all cancers in women worldwide, has a 15% death rate, and incidence rates are increasing at a rate of about 0.5% per year. Breast cancer comprises a heterogeneous group of tumor subtypes, whether defined by the histopathology of the primary tumor, the expres...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030881 | Pride
Human Tmt Breast cancer Drug resistance 
GenomicsTMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties
PRJNA922756 | ENA
ProteomicsLowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach
Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation (IP) of phosphotyrosine (pY) peptides prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to profile kinase substrates. A typical protocol request...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD019764 | Pride
Signaling Phosphotyrosine Label free quantification Lung cancer Lc-ms/ms 
ProteomicsMitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer
TMT-MS of whole cell lysate collected from 22Rv1 castration-resistant prostate cancer cells treated with 5 µM JG-98 for 4 hours.
ORGANISM(S): Homo Sapiens (human) 
2023-04-25 | PXD038684 | JPOST Repository
ProteomicsTMT data from ovarian cancer cells
In this project we want to compare ovarian cell cancer treated or non treated with cis-platinum. As acquisition strategy we have used a Real Time Search MS3 method in an Orbitrap Eclipse. The acquisition cycle began with an MS1 scanwhere the most intense ions were selected for fragmentation in the i...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD041002 | Pride
Tmt cancer 
ProteomicsA systematic comparison of label-free, SILAC and TMT techniques to study early adaption towards inhibition of EGFR signaling in the colorectal cancer cell line Difi
The epithelial growth factor receptor (EGFR) signalling network plays an essential role inproliferation and survival of colorectal cancer cells. For this reason, EGFR is targeted using therapeutic antibodies blocking EGFR signalling (e.g. cetuximab). However, anti-EGFR therapy is rarely curative as ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-11 | PXD014565 | Pride
Phosphoproteomics Tmt Anti-egfr therapy Colorectal cancer Silac Mapk Label-free Erbb3 Adaptive mechanism Cetuximab 
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