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ProteomicsRevelation of AbfR in Regulation of Mismatch Repair and Energy Metabolism in S. epidermidis by Integrated Proteomic and Metabolomic Analysis
Staphylococcus epidermidis is a common causative of nosocomial infections associated with indwelling medical devices. To date, the mechanisms of the pathogenicity and drug resistance of S. epidermidis have not been clearly elucidated. AbfR has been previously identified as an oxidation-sensing regul...
ORGANISM(S): Staphylococcus epidermidis RP62A Bacteria 
2020-07-29 | PXD020096 | Pride
Tmt10-plex labelling Staphylococcus epidermidis 
ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
ProteomicsLC-MS/MS analysis of tumour interstitial fluid from human breast cancers
Proteomics analysis of interstitial fluid from 35 human breast cancers.
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD001686 | Pride
Breast cancer Interstitial fluid 
ProteomicsTMTpro: Design and initial evaluation of a novel Proline-based isobaric 16-plex Tandem Mass Tag reagent set
The design and synthesis of a novel proline-reporter-based isobaric Tandem Mass Tag 16 tag set (TMTpro) was carried out and the data uploaded here is a comparison of the performance of the new TMTpro tags with the current commercially available dimethylpiperidine-reporter-based TMT10/11 reagents. Da...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Rattus norvegicus (Rat) 
2019-11-25 | PXD014750 | Pride
Tmt Tmtpro 
ProteomicsPolyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model
Supplementation of the mother's diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-08-12 | PXD033684 | Pride
Hydroxytyrosol  hippocampus  intrauterine growth restriction  brain  pig  proteome  tmt labelling 
UnknownRole of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.
Not available
S-EPMC5438363 | biostudies-literature
ProteomicsMCF7 xenografts with 5-FU in vivo ITDR-CETSA
MCF7 xenograft-bearing mice were treated intravenously for 22h with either vehicle or different 5-FU doses (10, 50, 100, and 150 mg/kg). Each xenograft was cut in similar-sized pieces and assembled into an ITDRCETSA scheme with 2 different heating temperatures (37ºC, 52ºC) and 3 xenograft pieces for...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026470 | JPOST Repository
ProteomicsHost-defence peptide caerin 1.1 and 1.9 inhibited the proliferation of glioblastoma cells
Glioblastoma, the most aggressive form of brain cancer, remains a significant global contributor to mortality. Predictions of its increasing incidence in the coming decades underscore the need for more effective treatment strategies. Caerin 1.1 and 1.9, host defence peptides originally isolated from...
ORGANISM(S): Homo sapiens (Human) 
2024-06-08 | PXD044941 | Pride
Glioblastoma Caerin peptide Apoptosis Lc-ms/ms 
ProteomicsProteomic analysis of anti-MRSA activity of caerin 1.1/1.9 in a murine skin infection model
Caerin 1 is a family of host-defense peptides with antimicrobial property originally isolated from Australia tree frog. Caerin 1.1+1.9 has been shown to inhibit multiple antibiotic resistant bacteria infection both in vitro and in vivo. In current study, we compare the MICs of caerin 1.1/1.9 with c...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-11 | PXD044425 | Pride
Proteomics Anti-mrsa Caerin peptide 
ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
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