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ProteomicsAbsolute Protein Quantitation of the Mouse Macrophage Toll-Like Receptor and Chemotaxis Pathways
The Toll-like receptor and chemotaxis pathways are key components of the innate immune system. Computational modeling and simulation at the molecular interaction level can be used to study complex biological pathways, but protein concentration values must be input as model parameters. In this invest...
ORGANISM(S): Mus Musculus 
2022-08-15 | PXD031697 | panorama
TranscriptomicsHuman Toll-Like Receptors Pathway Array Data
Endothelial cell (EC) Toll-like receptor 2 (TLR2) activation upregulates the expression of inflammatory mediators and of TLR2 itself, and modulates important endothelial functions, including coagulation and permeability. We defined TLR2 signaling pathways in ECs, and tested the hypothesis that TLR2 ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33449 | biostudies-arrayexpress
TranscriptomicsMalaria primes the innate immune response due to IFNg induced enhancement of Toll-like receptor expression and function.
Patients with febrile malaria were recruited in order to determine Peripheral Blood Mononuclear Cell (PBMC) gene expression during malaria. Blood was harvested from patients during the acute phase of the illness, and then patients were given a curative regimen of antimalarials. Three to four weeks...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-15221 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
ProteomicsIdentification of Toll-like receptor 4 interacting partner through immunoprecipitation-based chemical cross-linking proteomics
Toll-like receptor 4 (TLR-4) is a transmembrane protein. Its activation leads to NF-kB signaling pathway and proinflammatory cytokines’ production that are responsible for activating innate immunity system. Here, we design a co-immunoprecipitation based cross-linking proteomics approach to reveal th...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD014661 | Pride
Lps Hek293 Statin Tlr Toll like receptor 
TranscriptomicsTranscription profiling of wild type, Atf3(-/-), Ticam1(-/-), MyD88(-/-) and CREM(-/-) murine bone marrow-derived macrophages stimulated with purified Toll-like receptor agonists after 0-48 hours
Time course data from purified Toll-like receptor agonist-stimulated wild_type and knockout murine bone marrow-derived macrophages were collected to investigate the transcriptional network in TLR-activated macrophages.
ORGANISM(S): Mus musculus 
2008-03-26 | E-TABM-310 | biostudies-arrayexpress
TranscriptomicsConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
This SuperSeries is composed of the following subset Series: GSE19482: Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS) GSE19490: Transcriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS) GSE19765: Transcriptional responses of human...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19492 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary human macrophages over the course of HIV-1 infection reveals HIV-1 activates macrophages independent of Toll-like receptors
Macrophages provide an interface between innate and adaptive immunity and are important long-lived reservoirs for Human Immunodeficiency Virus Type-1 (HIV-1). Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated ...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-GEOD-13395 | biostudies-arrayexpress
TranscriptomicsSuppression of molecular inflammatory pathways by Toll-like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR a...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
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