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ProteomicsAbsolute Protein Quantitation of the Mouse Macrophage Toll-Like Receptor and Chemotaxis Pathways
The Toll-like receptor and chemotaxis pathways are key components of the innate immune system. Computational modeling and simulation at the molecular interaction level can be used to study complex biological pathways, but protein concentration values must be input as model parameters. In this invest...
ORGANISM(S): Mus Musculus 
2022-08-15 | PXD031697 | panorama
TranscriptomicsHuman Toll-Like Receptors Pathway Array Data
Endothelial cell (EC) Toll-like receptor 2 (TLR2) activation upregulates the expression of inflammatory mediators and of TLR2 itself, and modulates important endothelial functions, including coagulation and permeability. We defined TLR2 signaling pathways in ECs, and tested the hypothesis that TLR2 ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33449 | biostudies-arrayexpress
TranscriptomicsMalaria primes the innate immune response due to IFNg induced enhancement of Toll-like receptor expression and function.
Patients with febrile malaria were recruited in order to determine Peripheral Blood Mononuclear Cell (PBMC) gene expression during malaria. Blood was harvested from patients during the acute phase of the illness, and then patients were given a curative regimen of antimalarials. Three to four weeks...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-15221 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary human macrophages over the course of HIV-1 infection reveals HIV-1 activates macrophages independent of Toll-like receptors
Macrophages provide an interface between innate and adaptive immunity and are important long-lived reservoirs for Human Immunodeficiency Virus Type-1 (HIV-1). Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated ...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-GEOD-13395 | biostudies-arrayexpress
TranscriptomicsCross-talk between 4-1BB and TLR1-TLR2 signaling in CD8+ T cells regulates TLR2’s costimulatory effects
The activation of TLR-MyD88 (Toll like receptor- Myeloid differentiation factor 88) signaling within T cells functions as a potent costimulatory signal that boosts antitumor and antiviral responses. However, the molecular mechanisms underlying the costimulatory processes are poorly understood. We co...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-79475 | biostudies-arrayexpress
ProteomicsAn Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like receptor Signaling
Building an integrated view of cellular responses to environmental cues remains a fundamental challenge due to the complexity of intracellular networks in mammalian cells. Here we introduce an integrative biochemical and genetic framework to dissect signal transduction events using multiple data typ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-05-10 | MSV000081071 | MassIVE
TranscriptomicsSuppression of molecular inflammatory pathways by Toll-like Receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation of Toll-like receptors (TLRs) 7, 8 and 9 contributes to the initiation and maintenance of psoriasis. We have evaluated the effects of TLR a...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-50400 | biostudies-arrayexpress
ProteomicsIdentification of Toll-like receptor 4 interacting partner through immunoprecipitation-based chemical cross-linking proteomics
Toll-like receptor 4 (TLR-4) is a transmembrane protein. Its activation leads to NF-kB signaling pathway and proinflammatory cytokines’ production that are responsible for activating innate immunity system. Here, we design a co-immunoprecipitation based cross-linking proteomics approach to reveal th...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD014661 | Pride
Lps Hek293 Statin Tlr Toll like receptor 
ProteomicsDeep Succinylproteomics of Brain Tissues of Intracerebral Hemorrhage with inhibition of Toll-like receptor 4 signaling
The details of Toll-like receptor (TLR) 4 signaling affects protein succinylation in intracerebral hemorrhage (ICH) brains remains completely unclear. In this study, we constructed mice ICH models to investigate the changes in ICH-associated brain protein succinylation with the treatment of TLR4 ant...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025622 | Pride
Intracerebral hemorrhage  brain injury  succinylation  toll-like receptor 4 
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