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TranscriptomicsGamma-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiation
CD34+ HPC cells were retrovirally transduced with either control PINCO-GFP or PINCO Gamma-Catenin-GFP and analysed for Affymetrix mRNA expression. Gamma-Catenin and control matched transduced cells were also cultured until day 6 and were fractionated into the main progenitor groups for Affymetrix m...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-MEXP-3810 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of quiescent and cytokine induced normal human haematopoietic CD34+ HSPCs, and AML blast cells
Control group is an essential part of the research design which provide a baseline by elimating variables, bias and other factors that skew the data. Human CD34+ cells are generally used as controls to study myeloid malignancies. This study determines whether fresh or short term cytokine induced CD3...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-MTAB-3328 | biostudies-arrayexpress
TranscriptomicsIntegrated nuclear proteomics and transcriptomics identifies new high frequency dysregulated targets in acute myeloid leukemia
Acute myeloid leukemia (AML) is characterized by developmental arrest which is thought to arise from transcriptional dysregulation of myeloid development programs. Here, we have analyzed the transcriptome of AML blasts in comparison with normal human CD34+ cells using the HTA 2.0 gene chip. We have ...
ORGANISM(S): Homo sapiens 
2019-10-02 | E-MTAB-3873 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal progenitor cells mutated for RUNX1-RUNX1 during myeloid and erythroid development to identify genes disregulated by RUNX1-RUNX1
In order to identify genes dysregulated by the aberrant transcriptional activity of RUNX1-RUNX1T1, we used microarrays to determine the effect of this mutation on gene expression during myeloid and erythroid development of normal human progenitor cells.
ORGANISM(S): Homo sapiens 
2007-10-01 | E-MEXP-583 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation mediated by ROS in normal human haematopoietic progenitor cells expressing mutant N-RASG12D
The current study investigated the effect of RAS-induced ROS production on gene expression in normal human haematopoietic progenitor cells (HPC) using gene expression profiling (GEP) and assessed whether ROS-induced gene expression changes contributed to the pro-proliferative phenotype. In order to...
ORGANISM(S): Homo sapiens 
2015-11-30 | E-MTAB-3551 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of primary human basal cell carcinoma, squamous cell carcinoma, and normal skin
We used RNA microarray to investigate the expression of full-time and part-time sheddases and their substrates in basal cell carcinoma when compared to squamous cell carcinoma and normal skin. We aimed to identify the involvement of these sheddases in CD200 ectodomain shedding. RNA was extracted fro...
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12034 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the NK92MI cell line treated with CD200 peptide at 2hr and 4hr timepoints compared to untreated
We used RNA microarray to investigate CD200-mediated apoptosis on the NK92MI celll line. We aimed to identify apoptotic gene signatures. RNA was extracted from NK92MI cells and sent for sequencing. raw sequencing data was then processed in R using 'lumi' and 'limma' packages.
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12035 | biostudies-arrayexpress
UnknownImmunological insights into COVID-19 in Southern Nigeria.
Not available
S-EPMC10844438 | biostudies-literature
UnknownHumoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria.
Not available
S-EPMC9790078 | biostudies-literature
UnknownGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Not available
S-EPMC10208981 | biostudies-literature
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