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TranscriptomicsIdentification of glucose-TOR signaling early target genes in Arabidopsis seedling autotrophic transition stage
The goal of this experiment was to explore the molecular network of glucose-TOR signaling in Arabidopsis seedling autotrophic transition stage. We used the whole-genome microarrays to detail the global program of gene expression mediated by glucose and TOR. Arabidopsis WT and estradiol inducible RNA...
ORGANISM(S): Arabidopsis thaliana 
2013-04-05 | E-GEOD-40245 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis to study the involvement of the Tor pathway in the human-pathogenic fungus Aspergillus fumigatus
The Tor kinase is one of the major regulatory nodes in a eukaryotic cell and until now, little is known about this kinase in filamentous fungi. Here, we analysed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen of humans and the main causative agent of in...
ORGANISM(S): Aspergillus fumigatus CEA10 
2022-02-28 | PXD001601 | Pride
Proteomics Tor kinase Lc-ms/ms  tmt Fungi 
ProteomicsPost-translational regulation of photosynthetic activity via the TOR kinase in plants.
Chloroplasts are the powerhouse of the plant cell, and their activity must be matched to plant growth to avoid photo-oxidative damage. We have identified a post-translational mechanism linking the conserved Target of Rapamycin (TOR) kinase that promotes growth and the guanosine tetraphosphate (ppGpp...
ORGANISM(S): Nicotiana benthamiana 
2024-05-03 | PXD047124 | Pride
Photosynthesis Phosphorylation Tor kinase Guanosine tetraphosphate signaling Ppgpp 
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
TranscriptomicsIdentification of new target genes of TOR during growth in MDN
To identify novel targets of TOR when prototrophic strain S288c is grown in MDN media. Arrays compare growth in MDN with and without addition of rapamycin. For comparison, growth in YPD versus MDN as well as SCD versus MDN were examined as well.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-30 | E-GEOD-3157 | biostudies-arrayexpress
TranscriptomicsExploring the scope of TOR/PKA co-regulation in MDN
To identify genes co-regulated by TOR and PKA during growth in MDN BCY1, bcy1 deletion, TPK, and tpk1-3 deletion strains were grown in MDN with and without rapamycin treatment. Different combinations of these samples were examined.
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-3160 | biostudies-arrayexpress
Transcriptomicsrnai tor time course - The signalization way TOR/PTEN in Arabidopsis
gnp_blan06_torpten - rnai tor time course - The impact of the TOR pathway on growth and stress responses. Modification of translational and transcriptional profiles in Tor-inducible RNAi mutants and identification of TOR targets. 28 dye-swaps - normal vs. rnai mutant comparison.
ORGANISM(S): Arabidopsis thaliana 
2011-01-07 | E-GEOD-25701 | biostudies-arrayexpress
ProteomicsA systematic phosphoproteome screen to identify targets of the Target of Rapamycin (TOR) kinase in Arabidopsis thaliana
The target of rapamycin (TOR) kinase is a central regulatory hub that translates environmental and nutritional information into permissive or restrictive growth decisions. Although the TOR pathway is conserved among eukaryotes, plants developed unique adaptations to this pathway to cope with their a...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-07-17 | PXD008355 | Pride
Arabidopsis Sucrose Azd8055 Target of rapamycin (tor) Cell culture Label-free quantitative ms Phosphoproteomics Rapamycin 
TranscriptomicsGene profile of mid-log phase of SD medium grown Candida albicans rhb1 gene deletion strain
Candida albicans is an opportunistic pathogenic yeast that is commensally found in variety of host niches. Rhb1 serves as an positive regulator of Tor1 kinase which is the central component of the TOR signaling in controlling several virulence factors. Here, we used microarray to determined changes ...
ORGANISM(S): Candida albicans 
2012-03-15 | E-GEOD-29128 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes in TOR knockdown Arabidopsis lines
Rapamycin-sensitive transgenic Arabidopsis lines (BP12) expressing yeast FK506 Binding Protein12 (FKBP12) were developed. Inhibition of TOR in BP12 plants by rapamycin resulted in slower overall root, leaf and shoot growth and development leading to poor nutrient uptake and light energy utilization....
ORGANISM(S): Arabidopsis thaliana 
2012-12-18 | E-GEOD-42968 | biostudies-arrayexpress
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