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ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024695 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024768 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
ProteomicsPeroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A
Peroxiredoxins are modulators of aging in yeast and multicellular organisms. The mechanisms by which peroxiredoxins stimulate H2O2 resistance and slow down aging are, however, unclear. Here we show that the yeast peroxiredoxin Tsa1 boosts H2O2 resistance and prevents aging independent of cellular H2...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-07-27 | PXD012617 | Pride
Prm Yeast Oxidative stress Saccharomyces cerevisiae Lc-ms/ms 
TranscriptomicsFunctional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1
The cyclic AMP-protein kinase A pathway has a central role in the biology of Candida albicans, a prominent fungal pathogen of humans. The two catalytic subunits for cyclic AMP-dependent protein kinase, Tpk1 (orf19.4892) and Tpk2 (orf19.2277), have divergent roles, and most studies indicate a more pr...
ORGANISM(S): Candida albicans 
2012-08-07 | GSE38846 | GEO
UnknownFunctional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1.
Not available
S-EPMC3947901 | biostudies-literature
UnknownSalt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs).
Not available
S-EPMC3971370 | biostudies-literature
UnknownThe two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
Not available
S-EPMC1965580 | biostudies-literature
TranscriptomicsRPCC analysis of rap1-sil, tpk1 & tpk2.
RPCC (RNA pol II ChIP-on-chip) experiments with different mutants that affect to the accumulation of non active RNA pol II along the yeast genome. Keywords: ChIP-chip There are 4 different strains: rap1-sil (without the silencing domain), RAP1 (both from Graham I.R. et al 1999) and tpk1 & tpk2 muta...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14077 | biostudies-arrayexpress
TranscriptomicsFunctional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1
The cyclic AMP-protein kinase A pathway has a central role in the biology of Candida albicans, a prominent fungal pathogen of humans. The two catalytic subunits for cyclic AMP-dependent protein kinase, Tpk1 (orf19.4892) and Tpk2 (orf19.2277), have divergent roles, and most studies indicate a more pr...
ORGANISM(S): Candida albicans 
2012-08-06 | E-GEOD-38846 | biostudies-arrayexpress
TranscriptomicsGRO analysis of rap1-sil, tpk1 & tpk2.
GRO (Genomic run-on) experiments with different mutants that affect to the accumulation of non active RNA pol II along the yeast genome. Keywords: Genomic run-on GRO There are 4 different strains: rap1-sil (without the silencing domain), RAP1(both from Graham I.R. et al 1999) and tpk1 & tpk2 mutant...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14080 | biostudies-arrayexpress
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