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TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 2]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 2] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune com...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47673 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 1]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 1] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune comp...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47672 | biostudies-arrayexpress
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of Staphylococcus aureus
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38-alpha MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome matur...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD020401 | Pride
Macrophage  phagosome Staphylococcus aureus  tpl-2  v-atpase 
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38 MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome maturation,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-24 | PXD020247 | Pride
Macrophage Bacteria Tpl-2 V-atpase Staphylococcus aureus Dmxl1 Phagosome 
TranscriptomicsTpl-2 small molecule project
Tpl-2 is a serine/threonine kinase that has been studied extensively in monocytes. Tpl-2 is believed to phosphorylate MEK1/2, which is upstream of ERK1/2, and regulates inflammatory gene expression in response to TLR and IL-1b receptor signaling. In the course of performing proof-of-concept studies ...
ORGANISM(S): Homo sapiens 
2019-07-01 | GSE84153 | GEO
TranscriptomicsMEK-dependent and -independent signaling events downstream of Tpl-2
Comparison of Tpl-2 small molecule inhibitor (SMI) versus MEK SMI activities in LPS-treated human monocytes will reveal a subset of genes that require Tpl-2 but are independent of MEK. Tpl-2 is a highly conserved (94% human versus mouse) serine-threonine kinase expressed in cells important to the in...
ORGANISM(S): Homo sapiens 
2019-07-01 | GSE84161 | GEO
UnknownABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Not available
S-EPMC419892 | biostudies-literature
UnknownRegulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
Not available
S-EPMC3979668 | biostudies-literature
UnknownTPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.
Not available
S-EPMC5560741 | biostudies-literature
GenomicsHomo sapiens
Tpl-2 small molecule project
PRJNA328172 | ENA
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