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ProteomicsDMXL1 interaction proteomics from U2OS cells
To identify protein interactions with DMXL1, U2OS cells were engineered to either stably over-express DMXL1 tagged with mNeonGreen (mNG) or express HA-dTAG-tagged DMXL1 from the endogenous locus. Tagged DMXL1 was pulled-down by immunoprecipitation (IP) and IP samples were processed for TMT-MS analys...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD054967 | Pride
Lysosome Dmxl1 V-atpase Dmxl2 U2os 
ProteomicsCross-linking mass spectrometry of DMXL1-mNG immunoprecipitated complex
To capture protein interactions, cross-linking experiments were performed on immune complexes prepared by affinity-purification of DMXL1-mNG from U2OS cells.
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD054973 | Pride
Cross-linking Dmxl1 V-atpase Dsso 
ProteomicsDMXL1 interaction proteomics from U2OS cells infected with SidK
To assess the effect of SidK expression on DMXL1 interaction with the V1 subunits of the V-ATPase, U2OS cells stably expressing DMXL1 tagged with mNeonGreen (mNG) were infected with lentivirus to express either mCherry or mCherry-SidK. Post-infection, cells were harvested to perform immunoprecipitat...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD061791 | Pride
Lysosome Dmxl1 V-atpase Sidk U2os 
UnknownDMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation.
Not available
S-EPMC12246789 | biostudies-literature
UnknownDmxl1 is required for survival in the mouse to organogenesis stages of development.
Not available
S-EPMC12765052 | biostudies-literature
UnknownDmxl1 Is an Essential Mammalian Gene that Is Required for V-ATPase Assembly and Function In Vivo.
Not available
S-EPMC11237898 | biostudies-literature
UnknownSecondary leiomyosarcoma of the nasal cavity in a treated patient with possible hereditary retinoblastoma with germline reciprocal translocation of RB1 and DMXL1 and somatic TP53 mutation: A case report.
Not available
S-EPMC10407467 | biostudies-literature
ProteomicsHuman cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification and viral assembly
Human cytomegalovirus (HCMV) is an important human pathogen and a master regulator of host intrinsic, innate, and adaptive immunity. HCMV hijacks host intracellular compartments to assemble new virions, and lysosomes are essential for this process. We combined a comprehensive proteomic analysis of h...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2024-03-13 | PXD044273 | Pride
Proteomics  systems virology  human cytomegalovirus  lysosome  ph  viral replication  viral assembly  autophagy 
ProteomicsTPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria
Tumor Progression Locus 2 (TPL-2) kinase mediates Toll-like Receptor (TLR) activation of ERK1/2 and p38 MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase-independent regulatory function for TPL-2 in phagosome maturation,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-24 | PXD020247 | Pride
Macrophage Bacteria Tpl-2 V-atpase Staphylococcus aureus Dmxl1 Phagosome 
UnknownA heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients.
Not available
S-EPMC12527914 | biostudies-literature
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