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GenomicsInternational Verapamil SR/Trandolapril [INVEST] Genes Study
International Verapamil SR/Trandolapril [INVEST] Genes Study
PRJNA686451 | ENA
GenomicsInternational Verapamil SR/Trandolapril [INVEST] Genes Study
International Verapamil SR/Trandolapril [INVEST] Genes Study
PRJNA686452 | ENA
ProteomicsRegulation of mechanical intercellular junctions and components of the mitochondrial electron transport chain and the TCA cycle in the hypertrophic heart by pyridostigmine or trandolapril
The conventional approach to studying hypertension and cardiac hypertrophy primarily focuses on electrochemical signaling mediated by gap junctions. However, mechanical adherens junctions also contribute to hypertrophy through activation of β-catenin, promoting transcription of growth-inducing genes...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-07 | PXD076994 | Pride
Hypertrophy Pyridostigmine Trandolapril Electron transport chain Tca cycle Shr rats Desmosome Adherens junction Sarcomere 
UnknownImpact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers.
Not available
S-EPMC8301577 | biostudies-literature
UnknownCES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.
Not available
S-EPMC4865408 | biostudies-literature
UnknownTrandolapril Attenuates Pro-Arrhythmic Downregulation of Cx43 and Cx40 in Atria of Volume Overloaded Hypertensive and Normotensive Rats.
Not available
S-EPMC12562952 | biostudies-literature
UnknownThe treatment with trandolapril and losartan attenuates pressure and volume overload alternations of cardiac connexin-43 and extracellular matrix in Ren-2 transgenic rats.
Not available
S-EPMC10684879 | biostudies-literature
UnknownA Prospective Noninterventional, Observational Study to Describe the Effectiveness and Safety of Trandolapril and Verapamil Single-Pill Combination in the Management of Patients with Hypertension and Type 2 Diabetes Mellitus: A Harvest TR Study.
Not available
S-EPMC7492926 | biostudies-literature
UnknownLong-Term Mortality in Hypertensive Patients With Coronary Artery Disease: Results From the US Cohort of the International Verapamil (SR)/Trandolapril Study.
Not available
S-EPMC5063713 | biostudies-literature
ProteomicsModulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies
The consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. Here, the efficacy of pyridostigmine (PYR) and trandolapril (TRA) as antihypertensive and antihypertrophic agents was investigated and...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-09-10 | PXD050397 | Pride
Cholinergic signaling Pyridostigmine Trandolapril Acetylcholinesterase Hypertension Myocardial proteome Shr and wky rats 
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