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MetabolomicsLysine acetyltransferase Rv0998 coordinates transcriptional and metabolic adaptation of Mycobacterium tuberculosis to acidic pH

Mycobacterium tuberculosis (Mtb) survives host defences by adapting to host conditions, including acid stress, during infection. A critical survival strategy involves pH homeostasis, mediated by complex signalling systems that regulate metabolic reprogramming and stress responses. While ...

2026-09-03 | MTBLS15171 | MetaboLights
MetabolomicsEpigenetic coordination of transcriptional and translational programs in hypoxia

Adaptation to cellular stresses entails an incompletely understood coordination of transcriptional and post-transcriptional gene regulation. Here, we quantified hypoxia-dependent transcriptomes, epigenomes and translatomes in T47D breast cancer cells and H9 human embryonic stem cells. This reveal...

2025-06-09 | MTBLS12086 | MetaboLights
MetabolomicsTranscriptome-and metabolome-based mechanisms of high-temperature adaptation in triploid rainbow trout (Oncorhynchus mykiss)

High-temperature stress critically challenges cold-water aquaculture; however, the size-dependent molecular mechanisms underlying thermal adaptation in triploid rainbow trout (Oncorhynchus mykiss) remain poorly understood. Here, we integrated transcriptomic and metabolomic profiling of liver tiss...

2026-05-17 | MTBLS14507 | MetaboLights
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
MetabolomicsTranscriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole

Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the start of the century, and sustainable...

2021-11-02 | MTBLS2559 | MetaboLights
MetabolomicsThe circadian clock of Populus affects physiological, transcriptional and metabolomic responses to osmotic and ionic components of salt stress

The circadian oscillator is an innate timing mechanism present in most organisms, including plants. In this study, Populus tremula × P. tremuloides (Populus) trees with reduced expression of circadian clock components were exposed to gradually increa...

2025-10-02 | MTBLS9552 | MetaboLights
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsPhotoperiod-mediated transcriptional and metabolic reprogramming confers salt stress tolerance via the ascorbate-glutathione cycle and phenylpropanoid pathway in Ginkgo biloba
Ginkgo biloba, one of the oldest extant relict tree species, is highly valued for its medicinal properties. However, soil salinization has emerged as a severe global ecological challenge, substantially restricting plant growth, development, and geographical distribution. While light signaling, parti...
2026-07-22 | MTBLS15130 | MetaboLights
ProteomicsTranscriptional adaptation after deletion of Cdc42 in primary T cells
Cdc42 is a Rho family GTPase known for its central role in cell polarity and cytoskeletal regulation. To understand the role of Cdc42 in polarised secretion from cytotoxic T lymphocytes (CTLs) we used CRISPR/Cas9 gene deletion. While Cdc42-deleted CTLs initially showed reduced secretion for up to tw...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD063348 | Pride
T cell Rho gtpase Crispr/cas9 Transcriptional adaptation Cdc42 
TranscriptomicsGene expression profile in yeast under physiological changes of stress adaptation and stress recovery
The data provide information expression profile in yeast for 5 different physioloigcal conditions during stress adpatation and stress recovery (normal growth, during stress adaptation, after stress adaptation, under stress recovery, after stress recovery) in yeast. The purpose of the study is to u...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-22 | E-GEOD-36599 | biostudies-arrayexpress
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