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Regulation of co-transcriptional splicing by RNA-binding protein PTBP1
• Polycomb (PcG) regulation is crucial for development across eukaryotes, but how PcG targets are specified is still incompletely understood. The slow timescale of cold-induced Polycomb Repressive Complex 2 silencing during vernalization at Arabidopsis thaliana FLOWERING LOCUS C (FLC) provides an ex...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-13 | PXD036548 | Pride
Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells
Regulation of pre-mRNA splicing by m6A through the low-complexity protein hnRNPG and co-transcriptional pausing
Polycomb (PcG) silencing is crucial for development, but how targets are specified remains incompletely understood. The cold-induced Polycomb Repressive Complex 2 (PRC2) silencing of Arabidopsis thaliana FLOWERING LOCUS C (FLC) provides an excellent system to elucidate PcG regulation. Association...
ORGANISM(S): Arabidopsis Thaliana 
2022-08-15 | PXD036057 |
Higher plants encode four or five DICER-LIKE (DCL) enzymes responsible for the production of small non-coding RNAs which function in RNA interference (RNAi). Different RNAi pathways in plants effect transposon silencing, antiviral defense and endogenous gene regulation. DCL2 acts genetically redunda...
ORGANISM(S): Arabidopsis Thaliana 
2024-07-26 | PXD046163 | panorama
We examined the role of PTBP1 in regulation of co-transcriptional splicing process by depleting this RNA-binding protein from embryonic stem cells using the auxin-inducible degron technology and analysing the total and chromatin-associated RNA fractions by RNA-seq. We also performed mNET-seq and ChI...
ORGANISM(S): Mus musculus 
Global co-transcriptional splicing in Arabidopsis and the correlation with splicing regulation in mature RNAs
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