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ProteomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
We describe circadian clock-dependent changes in ribosome composition in Neurospora crassa depending on cell type, stress, or developmental state. Mass spectrometry of ribosomes isolated at different circadian times identified six ribosomal proteins and one ribosome-associated protein with clock-con...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) 
2024-10-15 | MSV000096101 | MassIVE
ProteomicsSystematic detection of amino acid substitutions in proteomes reveals a mechanistic basis of ribosome errors and selection for translation fidelity
The translation machinery and the genes it decodes co-evolved to achieve production throughput and accuracy. Nonetheless translation errors are frequent and they affect physiology and protein evolution. Mapping translation errors in proteomes and understanding their causes was hindered by lack of a ...
ORGANISM(S): Escherichia coli 
2019-07-29 | PXD014341 | Pride
Translation  ribosome errors  mispairing  misloading  mass spectrometry 
GenomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity [RNA-Seq]
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity [RNA-Seq]
PRJNA1188121 | ENA
GenomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity [Ribo-Seq]
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity [Ribo-Seq]
PRJNA1188122 | ENA
ProteomicsHuman TRMT2A methylates different components of the translation machinery and contributes to translation fidelity
Methyl-5-uridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme of m5U conversion at tRNA position 54. However, its RNA binding specificity and functional role in the cell are not well unders...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036538 | Pride
Rna biogenesis Translational fidelity Methyl-5-uridine (m5u) Rna methylation Trna methyltransferase 2 homolog a (htrmt2a) Interactome Mammalia 
UnknownTranslation fidelity coevolves with longevity.
Not available
S-EPMC5595694 | biostudies-literature
ProteomicsFidelity of translation initiation is required for coordinated respiratory complex assembly
Mammalian mitochondrial ribosomes are unique molecular machines that translate 11 leaderless mRNAs. To date it is not clear how mitoribosomes recognize and initiate translation in the absence of untranslated regions in the mitochondrial mRNAs. Translation initiation in mitochondria shares similariti...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-02 | PXD015521 | Pride
Ribosome Translation Cardiomyopathy Rna-seq 
OtherCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity [Ribo-Seq]
Ribosome composition can vary depending on cell type, stress or developmental state. Here we describe circadian clock-dependent changes in ribosome composition in Neurospora crassa. Mass spectrometry of ribosomes isolated at different circadian times identified six ribosomal proteins and one ribosom...
ORGANISM(S): Neurospora crassa 
2025-10-26 | GSE282318 | GEO
TranscriptomicsCircadian clock control of ribosome composition promotes rhythmic translation and termination fidelity [RNA-Seq]
Ribosome composition can vary depending on cell type, stress or developmental state. Here we describe circadian clock-dependent changes in ribosome composition in Neurospora crassa. Mass spectrometry of ribosomes isolated at different circadian times identified six ribosomal proteins and one ribosom...
ORGANISM(S): Neurospora crassa 
2025-10-26 | GSE282317 | GEO
GenomicsFidelity of translation initiation is required for coordinated respiratory complex assembly
Fidelity of translation initiation is required for coordinated respiratory complex assembly
PRJNA542722 | ENA
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