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TranscriptomicsDeep sequencing reveals mRNA recruitment in translation initiation
We studied the initiation signals located in the translational initiation region (TIR) and identified the role for recognition of the initiation signals in each individual stage during formation of the initiation complexes. Sequencing the randomized mRNA libraries captured by translation initiation ...
ORGANISM(S): Escherichia coli 
2016-07-27 | E-GEOD-69782 | biostudies-arrayexpress
TranscriptomicsGlucose depletion inhibits translation initiation in yeast - transcription profiling
This is a transcription profiling study on yeast undergoing glucose depletion. It reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss and 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-11 | E-MEXP-3037 | biostudies-arrayexpress
MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
TranscriptomicsGlucose depletion inhibits translation initiation in yeast - polysome and monosome profiling
This is a polysome/monosome profiling study on yeast undergoing glucose depletion. Polysomes and monosomes are extracted and the transcripts bound to each fraction are measured by microarray. The study reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-11 | E-MEXP-3038 | biostudies-arrayexpress
ProteomicsComputational prediction combined with proteogenomics unveils widespread non-AUG translation initiation events in plants
Non-AUG translation initiation is crucial for regulating translation, which can generate N-terminally extended protein isoforms with diverse biological functions. However, a comprehensive view of non-AUG translation initiation events with N-terminal extensions (NTEs) across monocots and dicots remai...
ORGANISM(S): Glycine max Zea mays (Maize) Oryza sativa (Rice) 
2026-04-27 | PXD058528 | Pride
Non-aug translation initiation  n-terminally extended protein isoforms  n-terminal extensions (ntes)  upstream translation initiation sites (utiss)  proteogenomics  monocots and dicots 
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis polysomal and non-polysomal RNA samples isolated from 10-day-old wild-type and eif3h mutant plants
Microarray comparisons of polysome loading in wild-type Arabidopsis and eif3h mutant; Goal: ; To find the target mRNAs that are translationally regulated by eIF3h. BACKGROUND: The eukaryotic translation initiation factor eIF3 has multiple roles during the initiation of translation of cytoplasmic mRN...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6024 | biostudies-arrayexpress
Transcriptomicsm6A in 5’ untranslated regions promotes cap-independent translation of mRNA
N6-methyladenosine (m6A) is a widespread internal RNA modification whose function is poorly understood. Here we report that m6A residues within the 5'UTR promote a novel form of cap-independent translation which is mediated through an interaction between m6A residues and the translation initiation f...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73405 | biostudies-arrayexpress
ProteomicsElucidation of the translation initiation factor interaction network of Haloferax volcanii reveals coupling of transcription and translation in haloarchaea
Translation is an important step in gene expression. Initiation of translation is rate-limiting, and it is 13 phylogenetically more diverse than elongation or termination. Bacteria contain only three initiation 14 factors. In stark contrast, eukaryotes contain more than 10 (subunits of) initiation f...
ORGANISM(S): Haloferax volcanii (Halobacterium volcanii) 
2021-09-29 | PXD028666 | Pride
Transcription Coupling Haloferax volcanii Ribosome Rna polymerase Translation initiation Aif Interaction networks 
TranscriptomicsTranscription profiling of Arabidopsis eif3h mutants vs. wild type
Microarray comparisons of transcript level in wild-type Arabidopsis and eif3h mutant plants. Goal:; To detect any change in transcript level between WT and eif3h mutant. BACKGROUND: The eukaryotic translation initiation factor eIF3 has multiple roles during the initiation of translation of cytoplasm...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6025 | biostudies-arrayexpress
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