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ProteomicsThe tricuspid valve also maladapts as shown in sheep with biventricular heart failure
Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients ...
ORGANISM(S): Ovis aries 
2021-09-09 | PXD022719 | Pride
Lc-ms/ms Tricuspid valve 
TranscriptomicsGene expression profile of calcified and normal tricuspid aortic valves by RNA sequencing.
Purpose: Calcific aortic valve stenosis (AS) is a fatal disease with currently no medical therapy. Some genes were associated with AS, but the genetic architecture of the disease has yet to be discovered. The objective of this study was to combine genome-wide association studies (GWAS) and gene expr...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-55492 | biostudies-arrayexpress
TranscriptomicsMiRNA microarray analysis of human bicuspid and tricuspid aortic valve leaflet tissues
Bicuspid aortic valve (BAV) is a common congenital cardiac anomaly, with an estimated incidence of 1-2%. It is responsible for the greatest burden of aortic valve disease in patients younger than 70 years in North America. We performed microRNA profiling in end-stage valve leaflets with BAV and TA...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-30197 | biostudies-arrayexpress
TranscriptomicsAdvanced Study of Aortic Pathology (ASAP)
BACKGROUND: The vast majority of thoracic aortic aneurysms (TAAs) are observed either together with a bicuspid aortic valve (BAV), a common congenital disorder, or in idiopathic cases such as patients with a normal tricuspid aortic valve (TAV). The main objective of our study was to identify shared ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-26155 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells
E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells; In the study we demonstrated shared gene expression in embryonic heart valve development and Osteoblast progenitor cells. The atrioventricular (AV) valves of the heart develop from undifferentiated mesen...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11040 | biostudies-arrayexpress
GenomicsGene expression profile from the bicuspid aortic valve(BAV), tricuspid aortic valve(TAV) and control samples.
Gene expression profile from the bicuspid aortic valve(BAV), tricuspid aortic valve(TAV) and control samples.
PRJNA1196812 | ENA
TranscriptomicsTranscription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves
Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TA...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-5180 | biostudies-arrayexpress
ProteomicsThe extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration
The molecular basis of aortic valve degeneration (AVD) is unclear. The extracellular matrix (ECM) of the valve is in dynamic reciprocity with its surrounding microenvironment and contains molecular traits of the pathophysiological processes. We compared abundances of ECM proteins from excised valve ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-03 | PXD025002 | Pride
Ecm Lc-ms/ms Human Aortic valve degeneration Extracellular matrix 
ProteomicsProteomics comparison of human valve interstitial cells from healthy patients and donors with CAVD
Calcific aortic valve disease (CAVD) is an slowly progressive calcification of heart valve which leads to aortic stenosis. The only existing treatment of CAVD is surgical replacment of calcified valve - development of anti-CAVD treatment is urgent task. For better understanding of molecular mechanis...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD032212 | Pride
Osteogenic differentiation Q exactive Valve interstitial cells Cavd 
UnknownClip Liberation to Facilitate Transcatheter Tricuspid Valve Replacement (CLEFT).
Not available
S-EPMC12441388 | biostudies-literature
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