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MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
MetabolomicsThe Influence of Sugar, Artificial Sweeteners, and the Microbiome on Rodent Triglyceride Composition (part III)
Not available
ORGANISM(S): Rattus norvegicus 
ST000960 | MetabolomicsWorkbench
TranscriptomicsThe transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
Here we report that the transcription factor cyclic AMP–responsive element–binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H–deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance ca...
ORGANISM(S): Mus musculus 
2011-06-04 | E-GEOD-29643 | biostudies-arrayexpress
Metabolomicsp53 K316P mutation results in increased liver triglyceride levels and increased rates of de novo lipogenesis.
Not available
ORGANISM(S): Mus musculus 
ST002396 | MetabolomicsWorkbench
ProteomicsLoss of adipose triglyceride lipase aids cancer growth in 3D
Shotgun proteomic analysis of 3D-grown or on CAM-assay grown lung cancer cells lacking or expressing the major triglyceride lipase adipose triglyceride lipase (ATGL)
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2021-05-21 | PXD021105 | Pride
Lung cancer Atgl Spheroids 
TranscriptomicsFenofibrate increases VLDL-triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
The PPAR? activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced VLDL-TG clearance and decreased VLDL-TG production. However, since data on the effect of fenofibrate on VLDL production are controversial, we aimed to investigate in (more) deta...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21211 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from JNK knocked down animals
Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor Coactivator 1 and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice. The c-Jun N-terminal kinases (JNKs) have been implicated in the development of insulin resistance, dia...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7648 | biostudies-arrayexpress
GenomicsHepatic GATA4 regulates cholesterol and triglyceride homoestasis
Hepatic GATA4 regulates cholesterol and triglyceride homoestasis
PRJNA875488 | ENA
ProteomicsTriglyceride induces ‌endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity
Triglyceride synthesis promotes the activation of C-type lectin receptors signaling pathway upon fungal infection‌. Triglyceride synthesis induces endoplasmic reticulum lipid bilayer stress and activates the PERK kinase after fungal stimulation. PERK mediates autophagic degradation of SHP-1 to ampli...
ORGANISM(S): Mus Musculus 
2026-01-12 | PXD072975 |
GenomicsTriglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 [RNA-seq]
Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 [RNA-seq]
PRJNA1210469 | ENA
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