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ProteomicsReadout of histone methylation by Trim24 locally restricts chromatin opening by p53
The genomic binding sites of the transcription factor (TF) and tumour suppressor p53 are unusually diverse in regards to their chromatin features, including histone modifications, opening the possibility that chromatin provides context-dependence for p53 regulation. Here, we show that the ability of...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD039553 | Pride
Trim24 p53 mouse 
ProteomicsInvestigation upon the state of p53 as well as interaction partners, in so much as can be learned from using the multi-component v5-dTag system.
Chromatin modifications provide additional context-dependence for DNA sequence-based gene regulation. Binding sites of the transcription factor (TF) and important tumour suppressor p53 are unusually diverse with regards to their chromatin accessibility and histone modifications, suggesting different...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD033674 | Pride
Trim24 Gene regulation Chromatin P53 
TranscriptomicsTrim24 knock down in the 2i-state of the mouse ES cells
Differentially expressed genes were determined by single-end sequencing (stranded protocol) following Trim24 and/or p53 knock down in the mouse ES cells grown in 2i media. Triplicates were generated for treatment and control samples but for p53 knock down (duplicate).
ORGANISM(S): Mus musculus 
2017-11-08 | E-MTAB-4893 | biostudies-arrayexpress
GenomicsChromatin opening by p53 is confined by Trim24 in a histone methylation-dependent manner [ChIP-seq]
Chromatin opening by p53 is confined by Trim24 in a histone methylation-dependent manner [ChIP-seq]
PRJNA825472 | ENA
GenomicsChromatin opening by p53 is confined by Trim24 in a histone methylation-dependent manner [RNA-seq]
Chromatin opening by p53 is confined by Trim24 in a histone methylation-dependent manner [RNA-seq]
PRJNA825471 | ENA
GenomicsChromatin opening by p53 is confined by Trim24 in a histone methylation-dependent manner [ATAC-seq]
Chromatin opening by p53 is confined by Trim24 in a histone methylation-dependent manner [ATAC-seq]
PRJNA825470 | ENA
GenomicsTrim24 knock down in the 2i-state of the mouse ES cells
Trim24 knock down in the 2i-state of the mouse ES cells
PRJEB14679 | ENA
GenomicsTrim24 knock down in the 2i-state of the mouse ES cells
Trim24 knock down in the 2i-state of the mouse ES cells
PRJEB17955 | ENA
Unknownp53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.
Not available
S-EPMC3289600 | biostudies-literature
GenomicsE-MTAB-4893
Transcription profiling by high throughput sequencing of mouse embryonic stem cells following Trim24 and/or p53 knockdown
2017-06-14 | E-MTAB-4893 | ExpressionAtlas
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