Sort   by:  
 Page size 
TranscriptomicsGata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development
The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcri...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12999 | biostudies-arrayexpress
ProteomicsThe Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with components of the Nuclear Receptor Corepressor Complex 1 and 2 (NCoR1 and NCoR2). Upon attenuation of Fgf signalling, unphosphorylated, nuclear Erf ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-26 | PXD037892 | Pride
Trophoblast stem cells Erf Ncor2 Ncor1 
UnknownMarmoset and human trophoblast stem cells differ in signaling requirements and recapitulate divergent modes of trophoblast invasion.
Not available
S-EPMC7616712 | biostudies-literature
GenomicsGenome-wide mapping of Eset-binding sites and H3K9me3 state in mouse embryonic stem cells
The histone H3 lysine 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells are normally unable to contribute to the trophectoderm (TE) in blastocysts, we find that depletion of Eset by shR...
ORGANISM(S): Mus musculus 
2009-11-04 | E-GEOD-17642 | biostudies-arrayexpress
GenomicsSUV39H2 CONTROLS TROPHOBLAST STEM CELL FATE
SUV39H2 CONTROLS TROPHOBLAST STEM CELL FATE
PRJNA647264 | ENA
TranscriptomicsEpigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-62150 | biostudies-arrayexpress
TranscriptomicsDifferentiation time course of trophoblast stem cells
To characterized the changes in gene expression during the differentiation of TS cells. TS cells can be derived from two time point during embryogenesis, cell lines tested were from each of these time points. Keywords: time course TS cells derived from either E3.5 or E6.5 embryos were differentiate...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12985 | biostudies-arrayexpress
ProteomicsIntegrated Multi-Omics Reveal Polycomb Repressive Complex 2 Restricts Human Trophoblast Induction
Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this property, naive cells are thought to lack chromatin-based lineage barriers. However, this assumption has not been tested. Here, we define the chromatin-associated proteome, histone post-translational modificati...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD032792 | Pride
H3k27me3 Trophoblast fate Polycomb repressive complex 2 (prc2) Chromatin proteomes Human pluripotent stem cells 
UnknownEpigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.
Not available
S-EPMC4263130 | biostudies-literature
GenomicsArid3a modulates the first cell fate decision by direct regulation of both embryonic and extraembryonic gene expression (ChIP-Seq)
Arid3a, a transcription factor known for its requirement in B-lymphocyte development, has been recently identified as a member of ES cell pluripotency network. Arid3a is moderately expressed in ES cells, and its expression is gradually increased during differentiation. Since Arid3a shows the highest...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-56876 | biostudies-arrayexpress
Sort   by:  
 Page size