Transcriptional profiling of hESCs differentiated towards an endodermal fate in chemically-defined media (3 days) compared to clones subjected to EOMES knockdown (via shRNA) under the same conditions.
Transcriptional profiling of hESCs in chemically-defined culture media compared to hESCs differentiated for 36h in the additional presence of FGF, LY294002 and either BMP or ActivinA.
Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective towards the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells (hESCs) to stud...
