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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
ProteomicsAgonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome
Natural compounds that can stimulate salivary secretion are of interest in developing treatments for xerostomia, the perception of a dry mouth, that affects between 10 and 30% of the adult and elderly population. Chemesthetic transient receptor potential (TRP) channels are expressed in the surface ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-16 | PXD017232 | Pride
Menthol Proteome Transient receptor potential channel agonists Nonivamide Saliva Cinnamaldehyde 
UnknownSystematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse.
Not available
S-EPMC3576292 | biostudies-literature
GenomicsIntegrated long- and short-read transcriptomics define TRP channel expression in adult mouse cortex
Integrated long- and short-read transcriptomics define TRP channel expression in adult mouse cortex
PRJNA1394928 | ENA
UnknownRegulation of the transient receptor potential channel TRPM3 by phosphoinositides.
Not available
S-EPMC4485019 | biostudies-literature
ProteomicsHierarchical antagonistic regulatory elements in the TRPV4 intrinsically disordered N-terminus modulate lipid binding and channel activity through transient long-range interactions
Intrinsically disordered regions (IDRs) are important for the functional regulation of membrane receptors. Among the TRP Vanilloid channels involved in thermo- and osmosensation, TRPV4 features the largest N-terminal IDR of ~150 residues. Here, we elucidate the structural ensemble of the TRPV4 IDR t...
ORGANISM(S): Gallus gallus (Chicken) 
2023-08-01 | PXD038153 | Pride
Trp channel Integrated structural biology Intrinsically disordered protein Long-range communication Pip2 binding 
TranscriptomicsIntegrated long- and short-read transcriptomics define TRP channel expression in adult mouse cortex
Transient receptor potential (TRP) ion channels are polymodal cation channels with well-established roles in peripheral sensory systems, whereas their expression landscape in the adult cerebral cortex remains incompletely defined. This study provides integrated Oxford Nanopore direct RNA sequencing ...
ORGANISM(S): Mus musculus 
2026-04-10 | GSE315051 | GEO
UnknownForty sites of TRP channel regulation.
Not available
S-EPMC11788071 | biostudies-literature
UnknownTRP channel expression correlates with the epithelial-mesenchymal transition and high-risk endometrial carcinoma.
Not available
S-EPMC8732886 | biostudies-literature
UnknownVAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
Not available
S-EPMC4742910 | biostudies-literature
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