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ProteomicsNascent proteome analysis of LN229 cells with Trp-starvation
Nascent proteome analysis of LN229 cells grown in tryptophan (Trp) depleted or standard cell culture medium for 10h
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD067012 | Pride
Trp-starvation Silac Newly-synthesized proteins Quanpa 
TranscriptomicsTryptophan restriction blocks MYC-driven tumorigenesis and reprograms cancer cells to rely on lipolysis
Cancer cells vary in their nutritional dependencies, thus characterization of nutrient demand of each tumor type is needed to uncover specific vulnerabilities. We demonstrate that MYC-driven liver tumors rely on increased tryptophan (Trp) uptake to grow. By following 13C-Trp in vivo-labeling, we fou...
ORGANISM(S): Mus musculus 
2023-09-30 | GSE213377 | GEO
UnknownCodon-Dependent Transcriptional Changes in Response to Tryptophan Limitation in the Tryptophan Auxotrophic Pathogens Chlamydia trachomatis and Streptococcus pyogenes.
Not available
S-EPMC8670374 | biostudies-literature
UnknownEffect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions.
Not available
S-EPMC11834466 | biostudies-literature
TranscriptomicsTryptophan metabolism response in E. coli
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli. We investigated the global changes in mRNA abundance in Escherichia coli elicited by various perturbations of tryptophan metabolism. To do so we printed ...
ORGANISM(S): Escherichia coli 
2001-07-30 | GSE7 | GEO
TranscriptomicsSingle cell fitness of B. subtilis correlates with the ability to adapt to various stresses.
How cells dynamically respond to fluctuating environmental conditions depends on the architecture and noise of the underlying genetic circuits. Most work characterizing stress pathways in the model bacterium Bacillus subtilis has been performed on bulk cultures using ensemble assays. However, invest...
ORGANISM(S): Bacillus subtilis 
2012-06-30 | E-GEOD-33506 | biostudies-arrayexpress
UnknownTryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.
Not available
S-EPMC11106337 | biostudies-literature
UnknownInhibition of tRNA Synthetases Induces Persistence in Chlamydia.
Not available
S-EPMC7093126 | biostudies-literature
UnknownThe alternative translational profile that underlies the immune-evasive state of persistence in Chlamydiaceae exploits differential tryptophan contents of the protein repertoire.
Not available
S-EPMC3372251 | biostudies-literature
UnknownUpregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.
Not available
S-EPMC6279332 | biostudies-literature
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