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TranscriptomicsTranscriptional signatures of regulatory and toxic responses to benzo(a)pyrene exposure in murine Hepa1c1c7 cells
Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding secondary effects of drugs and for eluci...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-29188 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-12-04-2016-13:32:15:134-286 - samples
RNA sequencing data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.
EGAD00001002011 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-12-04-2016-13:35:10:904-287 - samples
ChIPseq data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.
EGAD00001002012 | EGA
GenomicsDATA_SET_marlboro-EEP-2013-03-15 - samples
WGBS data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.
EGAD00001000366 | EGA
GenomicsWhole genome bisufite sequencing of smoking and non-smoking mother-child pairsBisufite sequencing, RNA-seq and ChIP-Seq data of whole blood samples from smoking and non-smoking mothers and their children at gestation/birth and follow-up years.
Whole-blood samples of 16 mother-child pairs with differing maternal smoking behaviour were bisulfite treated and sequenced with deep coverage to identify smoking-associated differentially methylated regions. RNA-sequencing and ChIP-sequencing of 4 chromatin marks complete the data set and allow for...
EGAS00001000455 | EGA
Genomicsena-DATASET-DKFZ-03-08-2020-18:14:14:560-2122 - samples
To investigate the immune response and mechanisms associated with severe COVID-19, we performed single-cell RNA-seq on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from 5 healthy controls. We identified airway epithelial ce...
EGAD00001006339 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsSingle-cell analysis of airway samples identifies immune cell activation correlating with COVID-19 disease severity
To investigate the immune response and mechanisms associated with severe COVID-19, we performed single-cell RNA-seq on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from 5 healthy controls. We identified airway epithelial ce...
EGAS00001004481 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsBIH COVID-19 airway single-cell data access committee.
Data Access Committee EGAC00001001627
EGAC00001001627 | EGA
Genomicsena-DATASET-DKFZ-24-12-2020-10:12:59:494-197 - samples
In Coronavirus Disease 2019 (COVID-19), hypertension and cardiovascular diseases are major risk factors for critical disease progression. However, the underlying reasons and the effect of the main anti-hypertensive therapies—angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin recep...
EGAD00001006828 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsHypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19
In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are major risk factors for critical disease progression. However, the underlying causes and the effects of the main anti-hypertensive therapies-angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor b...
EGAS00001004772 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
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