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TranscriptomicsExpression data from MCF-7 cells stimulated by Estrogen or IGF-I
Although estrogen receptor (ER) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer, cross-talk between these pathways, particularly at the level of gene transcription, remains poorly understood. We performed microarray analysis on MCF-7 bre...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-26834 | biostudies-arrayexpress
TranscriptomicsSAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells
The scaffold attachment factors SAFB1 and SAFB2 are paralogs, which are involved in cell cycle regulation, apoptosis, differentiation, and stress response. They have been shown to function as estrogen receptor co-repressors, and there is evidence for a role in breast tumorigenesis. To identify their...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-15548 | biostudies-arrayexpress
TranscriptomicsA Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenografts
Translational breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. In an effort to overcome these limitations, we propagated a cohort of human breast tumo...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-34412 | biostudies-arrayexpress
UnknownIntratumoral heterogeneity in a Trp53-null mouse model of human breast cancer.
Not available
S-EPMC4420701 | biostudies-literature
UnknownThe SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression.
Not available
S-EPMC4914345 | biostudies-literature
TranscriptomicsGene transcription signature of obesity in breast cancer
Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, insulin, and insulin-like growth factors (IGFs) that accelerate tumor cell proliferation and impair treatment response. We examined the effects of patie...
ORGANISM(S): Homo sapiens 
2011-07-17 | E-GEOD-24185 | biostudies-arrayexpress
UnknownResearch resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene.
Not available
S-EPMC2870939 | biostudies-literature
UnknownIdentification of tumor-initiating cells in a p53-null mouse model of breast cancer.
Not available
S-EPMC2459340 | biostudies-literature
TranscriptomicsTranscription profiling of mouse mammary gland side population cells (MG-SPs) to identify differentially expressed genes.
Similar to the bone marrow, the mammary gland contains a distinct population of Hoechst-effluxing side population cells, MG-SPs. To better characterize MG-SPs, their microarray gene profiles were compared to the remaining cells, which retain Hoechst dye (MG-NSPs). For analysis, gene ontology (GO) t...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5309 | biostudies-arrayexpress
UnknownInsulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.
Not available
S-EPMC2654368 | biostudies-literature
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