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ProteomicsCell surface interactome analysis identifies TSPAN4 as a negative regulator of PD-L1 in melanoma
PD-L1 functions as a co-inhibitory checkpoint ligand constraining anti-tumor immunity by binding to PD-1 on immune cells. Although antibody blockade therapy displays clear therapeutic responses, it is not effective in all cancer patients, indicating modulation by other factors. We applied cell surfa...
ORGANISM(S): Homo sapiens (Human) 
2026-01-16 | PXD064698 | Pride
Tspan4 Pd-l1 Melanoma Surface proximity biotinylation 
UnknownTSPAN4 influences glioblastoma progression through regulating EGFR stability.
Not available
S-EPMC11301097 | biostudies-literature
Genomics
TSPAN4 knockdown RNA-seq
PRJNA1121048 | ENA
UnknownCircular RNA circ-TSPAN4 promotes lung adenocarcinoma metastasis by upregulating ZEB1 via sponging miR-665.
Not available
S-EPMC6900391 | biostudies-literature
UnknownTSPAN4 controls vascular smooth muscle cell phenotypic switching and intimal hyperplasia by targeting TPM1-regulated cytoskeletal organization.
Not available
S-EPMC12687436 | biostudies-literature
UnknownIdentification of TSPAN4 as Novel Histamine H4 Receptor Interactor.
Not available
S-EPMC8394291 | biostudies-literature
UnknownTSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy.
Not available
S-EPMC9733225 | biostudies-literature
UnknownExploring TSPAN4 promoter methylation as a diagnostic biomarker for tuberculosis.
Not available
S-EPMC11048481 | biostudies-literature
UnknownExtracellular domain 2 of TSPAN4 governs its functions.
Not available
S-EPMC10982557 | biostudies-literature
ProteomicsGlioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4
Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes are organelles produced by highly migratory cells capable of mediating intercellular communication. Thus, GBM cells may produce migrasomes during migration. However, it remains unclear whe...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057558 |
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