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ProteomicsAutoregulation of tubulin mRNA via reversible TTC5 sequestration by soluble ab-tubulins
Microtubule cytoskeleton, built from heterodimers of α and β-tubulins, is critically important to physically organize cells, mediate intracellular transport and power cell division. The availability of soluble αβ-tubulins influences the biomechanical properties and functions of microtubules. When pr...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD050483 | Pride
Microtubules Ttc5 Hdx-ms Mrna Tubulin 
ProteomicsAutoregulation of tubulin mRNA via reversible TTC5 sequestration by soluble αβ-tubulins
The microtubule cytoskeleton, built from heterodimers of α and β-tubulins, is critically important to physically organize cells, mediate intracellular transport and power cell division. The availability of soluble αβ-tubulins influences the biomechanical properties and dynamic functions of microtubu...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD050557 | Pride
Αβ-tubulins Ttc5 
GenomicsTubulin autoregulation mediator TTC5 regulates neuronal morphology and migration
Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration
PRJNA1375555 | ENA
TranscriptomicsTubulin autoregulation mediator TTC5 regulates neuronal morphology and migration
Tetratricopeptide repeat domain 5 (TTC5) mediates the co-translational degradation of tubulin transcripts in response to excess soluble tubulin, a.k.a. “tubulin autoregulation”. TTC5 mutations associate with cerebral atrophy, speech and motor impairment; however, the role of TTC5 and tubulin autoreg...
ORGANISM(S): Homo sapiens 
2026-09-23 | GSE312628 | GEO
UnknownTTC5 mediates autoregulation of tubulin via mRNA degradation.
Not available
S-EPMC6942541 | biostudies-literature
UnknownTTC5 syndrome: Clinical and molecular spectrum of a severe and recognizable condition.
Not available
S-EPMC9541101 | biostudies-literature
UnknownSoluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay.
Not available
S-EPMC11570694 | biostudies-literature
UnknownBi-allelic TTC5 variants cause delayed developmental milestones and intellectual disability.
Not available
S-EPMC9648057 | biostudies-literature
UnknownEvaluation of the Role of p53 Tumour Suppressor Posttranslational Modifications and TTC5 Cofactor in Lung Cancer.
Not available
S-EPMC8707832 | biostudies-literature
ProteomicsMechanism of ribosome-associated mRNA degradation during tubulin autoregulation
Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis. The availability of free tubulin subunits impacts polymerization dynamics and microtubule function. When cells sense excess free tubulin, they trigger degradation of the encoding mRNAs, which requires rec...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD041096 | Pride
Orbitrap eclipse Q exactive plus Human lc-ms/ms 
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