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ProteomicsHDX-MS analysis of a TTC7B specific nanobody to inhibit EFR3 mediated PI4KA recruitment
Phosphatidylinositol 4 kinase III (PI4KIII/PI4KA) is an essential lipid kinase that is critical for regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through targeted recruitment by the proteins EFR3A and EFR3B, with these binding to the PI4KA accessory protein...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD066213 | Pride
Pi4ka Hdx-ms Nanaobody Ttc7b 
GenomicsMethylated RNA Immunoprecipitation sequencing Quantitative Analysis of HCT116 Wild Type and TTC7B-KO Transcriptomes
Methylated RNA Immunoprecipitation sequencing Quantitative Analysis of HCT116 Wild Type and TTC7B-KO Transcriptomes
PRJNA1108601 | ENA
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of HCT116 Wild Type and TTC7B-KO/OE Transcriptomes
Next Generation Sequencing Facilitates Quantitative Analysis of HCT116 Wild Type and TTC7B-KO/OE Transcriptomes
PRJNA1039246 | ENA
TranscriptomicsMethylated RNA Immunoprecipitation sequencing Quantitative Analysis of HCT116 Wild Type and TTC7B-KO Transcriptomes
To explore the function of TTC7B on colon cancer，we established HCT116 TTC7B-KO cell lines. The purpose of this study aims to predict possible downstream target genes of TTC7B and to investigate the effects of TTC7B knockout on modification of gene RNA m6A methylated RNA site by MeRIP-seq
ORGANISM(S): Homo sapiens 
2024-10-10 | GSE266858 | GEO
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of HCT116 Wild Type and TTC7B-KO/OE Transcriptomes
To explore the function of TTC7B on colon cancer，we established HCT116 TTC7B-KO/OE cell lines. The purpose of this study is to utilize next-generation sequencing techniques to investigate the effects of TTC7B knockout or overexpression on the biological behavior of tumor cells.
ORGANISM(S): Homo sapiens 
2024-10-10 | GSE247502 | GEO
UnknownDevelopment of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.
Not available
S-EPMC12747262 | biostudies-literature
UnknownDevelopment of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.
Not available
S-EPMC12765194 | biostudies-literature
UnknownTTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation.
Not available
S-EPMC11781174 | biostudies-literature
UnknownTTC7B is a new prognostic biomarker in head and neck squamous cell carcinoma linked to immune infiltration and ferroptosis.
Not available
S-EPMC10757123 | biostudies-literature
UnknownTTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches.
Not available
S-EPMC3367223 | biostudies-literature
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