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ProteomicsHDX-MS analysis of PI4Ka trimer and FAM126a (415-521) with calcineurin
We used HDX-MS to map novel binding sites of calcineurin on PI4KA and FAM126A. Calcineurin binds to PxIxIT and LxVP motifs on PI4KA and FAM126A indicating a novel regulatory mechanism of Pi4KA by calcineurin
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD050633 | Pride
Hdx-ms Pi4ka Fam126a Calcineurin 
ProteomicsHDX-MS analysis of a TTC7B specific nanobody to inhibit EFR3 mediated PI4KA recruitment
Phosphatidylinositol 4 kinase III (PI4KIII/PI4KA) is an essential lipid kinase that is critical for regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through targeted recruitment by the proteins EFR3A and EFR3B, with these binding to the PI4KA accessory protein...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD066213 | Pride
Pi4ka Hdx-ms Nanaobody Ttc7b 
ProteomicsDefining the molecular mechanism of PI4KA complex regulation by the phosphatase Calcineurin
To examine the interaction between PI4KIIIa and Calcineurin, HDX-MS experiments comparing calcineurin or PI4KA FAM delta C alone to the calcineurin and PI4KA FAM delta C complex were carried out.
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD043409 | Pride
Hdx-ms Pi4k Calcineurin 
ProteomicsHydrogen Deuterium Exchange of PI4K(530-560) Peptide with Calcineurin
we used HDXMS to study if PI4KA(530-560) is able to bind calcineurin. Here we showed a significant protection in deuterium exchange upon binding calcineurin in the wild type state, indicating these proteins are interacting. Using a mutant that should inhibit the interaction (AKASAA), we showed that ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD044636 | Pride
Hdxms Pi4k Calcineurin 
Genomics
PI4KA
PRJNA1284880 | ENA
GenomicsWhole Transcriptome Analysis (Rna-Seq) By Next-Generation Sequencing Of PI4KA-LCLs
Whole Transcriptome Analysis (Rna-Seq) By Next-Generation Sequencing Of PI4KA-LCLs
PRJEB72024 | ENA
Genomics
PI4KA-KO
PRJNA1302668 | ENA
UnknownIdentifying novel heterozygous PI4KA variants in fetal abnormalities.
Not available
S-EPMC11783698 | biostudies-literature
UnknownMolecular basis for plasma membrane recruitment of PI4KA by EFR3.
Not available
S-EPMC11092606 | biostudies-literature
UnknownMolecular basis for plasma membrane recruitment of PI4KA by EFR3.
Not available
S-EPMC11661448 | biostudies-literature
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