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ProteomicsHDX-MS analysis of PI4Ka trimer and FAM126a (415-521) with calcineurin
We used HDX-MS to map novel binding sites of calcineurin on PI4KA and FAM126A. Calcineurin binds to PxIxIT and LxVP motifs on PI4KA and FAM126A indicating a novel regulatory mechanism of Pi4KA by calcineurin
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD050633 | Pride
Hdx-ms Pi4ka Fam126a Calcineurin 
UnknownThe leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.
Not available
S-EPMC4689616 | biostudies-literature
UnknownFrequent loss of FAM126A expression in colorectal cancer results in selective FAM126B dependency.
Not available
S-EPMC11025007 | biostudies-literature
UnknownFAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway.
Not available
S-EPMC9072533 | biostudies-literature
ProteomicsHDX-MS Analysis of the PI4K EFR3A Complex
HDX-MS analysis examining the complex that forms between the subunits of PI4KIIIa and EFR3A
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD043442 | Pride
Hdx-ms Pi4ka Efr3a Fam126a Ttc7b 
ProteomicsHDX-MS analysis of a TTC7B specific nanobody to inhibit EFR3 mediated PI4KA recruitment
Phosphatidylinositol 4 kinase III (PI4KIII/PI4KA) is an essential lipid kinase that is critical for regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through targeted recruitment by the proteins EFR3A and EFR3B, with these binding to the PI4KA accessory protein...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD066213 | Pride
Pi4ka Hdx-ms Nanaobody Ttc7b 
UnknownMolecular basis for plasma membrane recruitment of PI4KA by EFR3.
Not available
S-EPMC11092606 | biostudies-literature
UnknownMolecular basis for plasma membrane recruitment of PI4KA by EFR3.
Not available
S-EPMC11661448 | biostudies-literature
UnknownPalmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane.
Not available
S-EPMC8523714 | biostudies-literature
UnknownDevelopment of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA.
Not available
S-EPMC12747262 | biostudies-literature
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