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UnknownNon-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging.
Not available
S-EPMC10461203 | biostudies-literature
ProteomicsTrichothiodystrophy-associated MPLKIP maintains DBR1 levels for correct mRNA splicing and ectodermal differentiation
The brittle hair syndrome Trichothiodystrophy (TTD) is characterized by variable clinical features, including photosensitivity, ichthyosis, growth retardation, microcephaly, intellectual disability, hypogonadism, and anemia. TTD-associated mutations typically cause unstable mutant proteins involved ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-09 | PXD044434 | Pride
Ttd Mplkip Splicing 
ProteomicsTrichothiodystrophy-associated MPLKIP maintains DBR1 levels for correct mRNA splicing and ectodermal differentiation
The brittle hair syndrome Trichothiodystrophy (TTD) is characterized by variable clinical features, including photosensitivity, ichthyosis, growth retardation, microcephaly, intellectual disability, hypogonadism, and anemia. TTD-associated mutations typically cause unstable mutant proteins involved ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-25 | PXD044779 | Pride
Splicing factor Mplkip Ttd 
TranscriptomicsGene expression profiles in Trichothiodystrophy patient and control
RNA-seq of primary fibroblasts from TTD patient and control
ORGANISM(S): Homo sapiens 
2021-06-29 | E-MTAB-10567 | biostudies-arrayexpress
UnknownConformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.
Not available
S-EPMC5743070 | biostudies-literature
TranscriptomicsTransient telomere dysfunction induces chromosomal instability and promotes carcinogenesis in telomerase-proficient mice
Background and Aims: Telomere dysfunction can increase tumor initiation by induction of chromosomal instability, but initiated tumor cells need to reactivate telomerase for genome stabilization and tumor progression. However, this concept has not been proven in vivo since appropriate mouse models we...
ORGANISM(S): Mus musculus 
2012-03-30 | E-GEOD-36813 | biostudies-arrayexpress
UnknownStructural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein.
Not available
S-EPMC3543016 | biostudies-literature
ProteomicsNucleolar TFIIE plays a role in ribosomal biogenesis and performance
Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiation site of protein-coding genes. Distinct mutations...
ORGANISM(S): Homo sapiens (Human) 
2021-11-16 | PXD023451 | Pride
Ribosome Translational fidelity Tfiie Rna polymerase i Proteostasis 
UnknownSmall molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.
Not available
S-EPMC6166727 | biostudies-literature
UnknownIs Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties.
Not available
S-EPMC8512846 | biostudies-literature
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