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ProteomicsMin protein in vitro protein expression kinetics
The Min biochemical network regulates bacterial cell division and is a prototypical example of self-organizing molecular systems. Cell-free assays relying on purified proteins have shown that MinE and MinD self-organize into surface waves on a planar membrane and into various oscillatory patterns in...
ORGANISM(S): Escherichia Coli 
2019-11-11 | PXD015686 | panorama
TranscriptomicsTranscription profiling of elicitor treatment over time (0, 30, 60 min) in Arabidopsis Landsberg (wt) and fls2-17 (flagellin receptor mutant)
Transcriptional changes upon elicitor treatment over time (0, 30, 60 min) have been analysed with the A.thaliana Landsberg (wt) and fls2-17 (flagellin receptor mutant).
ORGANISM(S): Arabidopsis thaliana 
2006-03-15 | E-MEXP-547 | biostudies-arrayexpress
ProteomicsSalmonella antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of EF-Tu P-loop
Rearrangement hot spots (Rhs) proteins are members of the broad family of polymorphic toxins. Polymorphic toxins are modular proteins composed of an N-terminal region that specifies their mode of secretion into the medium or into the target cell, a central delivery module and a C-terminal domain tha...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Bacteria 
2023-03-11 | PXD033100 | Pride
Elongation factor Adpribosylation Toxin Rearrangement hot spots T6ss P-loop Modification Translation 
ProteomicsThe Shewanella oneidensis Fic enzyme SoFic targets theswitch-I region of EF-Tu for AMPylation
Fic enzymes mediate diverse post-translational modifications, including adeno-sine monophosphate (AMP) transfer and removal, referred to as AMPylationand deAMPylation, respectively. We identified the prokaryotic translationelongation factor Tu (EF-Tu) as an AMPylation target of the Fic enzymeSoFic. ...
ORGANISM(S): Escherichia coli 
2026-09-18 | PXD071331 | Pride
Structural regulation Ampylation Ef-tu Fic enzymes Deampylation 
MetabolomicsDiscovery of urinary biomarkers to discriminate between exogenous and semi-endogenous thiouracil in cattle (Calf samples)
In the European Union, the use of thyreostats for animal fattening purposes has been banned because of their carcinogenic and teratogenic effects, whereby any residues in derived food products may hold a risk for human health. In this regard, potential abuse is monitored by targeted analysis of thyr...
2018-02-22 | MTBLS554 | MetaboLights
MetabolomicsDiscovery of urinary biomarkers to discriminate between exogenous and semi-endogenous thiouracil in cattle (Cow samples)
In the European Union, the use of thyreostats for animal fattening purposes has been banned because of their carcinogenic and teratogenic effects, whereby any residues in derived food products may hold a risk for human health. In this regard, potential abuse is monitored by targeted analysis of thyr...
2018-02-22 | MTBLS561 | MetaboLights
TranscriptomicsTranslational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection
Malaria is caused by Plasmodium parasites, which are transmitted via the bites of infected Anopheline mosquitoes. Midgut invasion is a major bottleneck for Plasmodium development inside the mosquito vectors as a rapidly responding immune system recognizes ookinetes and recruits killing factors from ...
ORGANISM(S): Anopheles gambiae 
2012-09-21 | E-GEOD-38707 | biostudies-arrayexpress
ProteomicsCSF levels of Elongation Factor Tu is associated with increased mortality in human Streptococcus pneumoniae meningitis
Background Mortality from bacterial meningitis, predominately caused by Streptococcus pneumoniae, exceeds 50% in low and middle income countries in sub-Saharan Africa with high HIV prevalence. Underlying causes of high mortality are poorly understood. We examined the host and pathogen proteome in a...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD021268 | Pride
Cerebrospinal fluid Proteomics Hiv Mortality Streptococcus pneumoniae 
ProteomicsDectin-1 recognizes bacterial EF-Tu during infection
Dectin-1 (CLEC7A) is a pattern-recognition receptor known for its essential role in antifungal defense, and may also be associated with antibacterial immunity. Here we show that in murine pneumonia models, Dectin-1 deficiency impaired pulmonary clearance of Streptococcus pneu-moniae and Haemophilus ...
ORGANISM(S): Haemophilus influenzae 2019 
2026-09-11 | PXD070889 | Pride
Dectin-1 Haemophilus influenzae 
ProteomicsImpact of exercise on the proteome of human peripheral blood mononuclear cells
This project aimed to characterize the impact of high-intensity interval exercise (HIIE) vs. moderate-intensity continuous exercise (MICE) on immune cell proteomics. In a randomized crossover study with 23 young, recreationally active runners, we isolated peripheral blood mononuclear cells (PBMCs) b...
ORGANISM(S): Homo sapiens (Human) 
2025-01-25 | PXD058573 | Pride
Exercise 
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