Sort   by:  
 Page size 
MetabolomicsConformational gating mechanism for processive catalysis of beta(1,3) -glucans

Processive catalysis is a fundamental molecular mechanism in nature to both build and dismantle complex biological polymers such as nucleic acids, proteins and carbohydrates, underpinning a broad spectrum of biotechnological applications. Here, we uncover a processive mechanism for the breakdown ...

2026-03-02 | MTBLS13959 | MetaboLights
ProteomicsPrimary myeloid cell proteomics and transcriptomics: importance of β-tubulin isotypes for osteoclast function
Among hematopoietic cells, osteoclasts (Oc) and immature dendritic cells (Dc) are closely related myeloid cells with distinct functions; Oc participate skeleton maintenance while Dc sample the environment for foreign antigens. Such specificities rely on profound modifications of gene and protein exp...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-16 | PXD018832 | Pride
Tubulin beta class v Tubb6 Rnaseq Silac Osteoclast Myeloid cell Tubulin 
TranscriptomicsGenome wide expression analysis of ER alpha and beta with or without E2 treatment in U2OS cell line.
Estrogen receptorï?  beta (ER beta) has potent anti-proliferative and anti-inflammatory properties, suggesting that ER beta-selective agonists might be a new class of therapeutic and chemopreventative agents. To understand how ER beta regulates genes, we identified genes regulated by the unliganded ...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21769 | biostudies-arrayexpress
TranscriptomicsProgenitor Cell Marker Aldehyde Dehydrogenase 1a3 Defines a Subset of Failing Pancreatic Beta Cells in Diabetic Mice
Insulin-producing beta cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, sets the stage for progression from beta cell dysfunction to beta cell dedifferentiation. In this study, we sought to ...
ORGANISM(S): Mus musculus 
2016-09-02 | E-GEOD-78966 | biostudies-arrayexpress
UnknownMolecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance.
Not available
S-EPMC2676035 | biostudies-literature
TranscriptomicsGenome wide analysis of ER beta in U2OS cells
This SuperSeries is composed of the following subset Series: GSE21769: Genome wide expression analysis of ER alpha and beta with or without E2 treatment in U2OS cell line. GSE21770: Genome-wide maps of ER beta binding sites in U2OS cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-05-11 | E-GEOD-21790 | biostudies-arrayexpress
UnknownClass V β-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes.
Not available
S-EPMC3069006 | biostudies-literature
UnknownA ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation.
Not available
S-EPMC452570 | biostudies-literature
TranscriptomicsCOUP-TFII Controls Mouse Postnatal Pancreatic β-Cell Mass through GLP-1 β-Catenin
Pancreatic β-cells have the key homeostatic function of releasing insulin to keep blood glucose in the normal range. It is not fully understood how β-cell mass is determined. Ablation of a nuclear receptor, chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), in mouse pancreat...
ORGANISM(S): Rattus norvegicus 
2011-10-06 | E-GEOD-30526 | biostudies-arrayexpress
GenomicsGenome-wide maps of ERbeta binding sites in U2OS cells
Estrogen receptor beta (ERbeta) has potent anti-proliferative and anti-inflammatory properties, suggesting that ER beta-selective agonists might be a new class of therapeutic and chemopreventative agents. To understand how ER beta regulates genes, we identified genes regulated by the unliganded and ...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-21770 | biostudies-arrayexpress
Sort   by:  
 Page size