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UnknownInsulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake.
Not available
S-EPMC7990718 | biostudies-literature
UnknownUbiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle.
Not available
S-EPMC9556833 | biostudies-literature
TranscriptomicsAn insulin-stimulated proteolytic mechanism links energy expenditure with glucose uptake
Mechanisms to coordinately regulate oxidative metabolism and glucose transport into cells are not well described. In muscle and fat, insulin mobilizes GLUT4 glucose transporters to the cell surface in part by stimulating the site-specific endoproteolytic cleavage of TUG proteins. Here, we show that ...
ORGANISM(S): Mus musculus 
2020-07-23 | GSE134846 | GEO
UnknownUnfolding the HIV-1 reverse transcriptase RNase H domain--how to lose a molecular tug-of-war.
Not available
S-EPMC4770237 | biostudies-literature
GenomicsAn insulin-stimulated proteolytic mechanism links energy expenditure with glucose uptake
An insulin-stimulated proteolytic mechanism links energy expenditure with glucose uptake
PRJNA556648 | ENA
UnknownHigh-fat diet ablates an insulin-responsive pool of GLUT4 glucose transporters in skeletal muscle.
Not available
S-EPMC12236751 | biostudies-literature
ProteomicsPeroxisomal targeting of the protein phosphatase Ptc5 via mitochondrial transit
Correct intracellular distribution of proteins is critical for the function of eukaryotic cells. Certain proteins are targeted to more than one cellular compartment, e.g. to mitochondria and peroxisomes. The protein phosphatase Ptc5 from Saccharomyces cerevisiae contains an N-terminal mitochondrial ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-22 | PXD018591 | Pride
Protein phosphatase Yeast Peroxisome Ptc5 
MetabolomicsFrailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility
As human society ages globally, age-related disorders are becoming increasingly common. Due to decreasing physiological reserves and increasing organ system dysfunction associated with age, frailty affects many elderly people, compromising their ability to cope with acute stressors. Frail elderly pe...
2020-05-01 | MTBLS1540 | MetaboLights
UnknownSustained caloric restriction potentiates insulin action by activating prostacyclin synthase.
Not available
S-EPMC12034231 | biostudies-literature
ProteomicsUnraveling the Interplay of Sustained Caloric Restriction and Adipose Tissue GLUT4 Translocation in Insulin Sensitivity Regulation
Caloric restriction (CR) is a well-established dietary strategy known to enhance insulin sensitivity and mitigate the risk of metabolic disorders. Despite its proven benefits, the precise molecular mechanisms underlying CR's positive impacts remain incompletely elucidated. Therefore, the principal g...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047731 | Pride
Caloric restriction Prostacyclin synthase Tug cleavage Proteomics Insulin sensitivity 
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