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MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
TranscriptomicsRegulation of Angiogenesis by EZH2
While VEGF-targeted therapies are showing promise in clinical studies, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homologue 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in ...
ORGANISM(S): Homo sapiens 
2010-10-12 | E-GEOD-20381 | biostudies-arrayexpress
TranscriptomicsExpression analysis of the glucose deprivation-induced human tumor cell responses
The tumor microenvironment is characterized by low glucose and hypoxia. It is well known that changes in the tumor microenvironment, such as hypoxia and low glucose, can increase the production of VEGF. Although the role of hypoxia in the regulation of VEGF production is well understood, the mechani...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-38583 | biostudies-arrayexpress
ProteomicsCancer associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer
WNT2 is important for placenta vascularization and acts as a pro-angiogenic factor for liver and other endothelial cells (ECs). WNT2 induction has been shown in many carcinomas and is associated with tumor progression. In colorectal cancer (CRC) WNT2 is selectively elevated in cancer associated fibr...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD014019 | Pride
Angiogenesis Colon cancer Cancer associated fibroblasts Tumor stroma Wnt2 Huvec 
TranscriptomicsSynergistic anti-tumor activity by association of MEK and PI3K/mTOR blockade with TRAIL in human melanoma
Combining direct anti-tumor effects with targeting of tumor microenvironment is an attractive strategy that may lead to more effective therapies for advanced melanoma. Here, we tested whether association of TRAIL with co-targeting of MEK and PI3K/mTOR, or with MEK blockade, could have synergistic a...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-55050 | biostudies-arrayexpress
GenomicsEndothelial Fat4 regulates tumor angiogenesis and tumor immunity
Endothelial Fat4 regulates tumor angiogenesis and tumor immunity
PRJNA1381626 | ENA
ModelsYang2012 - cancer growth with angiogenesis
The paper describes a model of tumor growth with angiogenesis. Created by COPASI 4.26 (Build 213) This model is described in the article: Mathematical modeling of solid cancer growth with angiogenesis Hyun M Yang Theoretical Biology and Medical Modelling 2012, 9:2 Abstract: Background: Cance...
2024-09-02 | BIOMD0000000796 | BioModels
TranscriptomicsTranscriptional profiling of tumor-associated blood vessels in invasive bladder cancer
Tumor-associated blood vessels differ from normal vessels at the morphological and molecular level. Proteins that are only present on tumor vessels may serve as biomarkers and as therapeutic targets for inhibition of angiogenesis in cancer. Comparing the transcriptional profiles of blood vascular en...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41614 | biostudies-arrayexpress
TranscriptomicsExpression Data from Normal or Tumor Fibroblasts With or Without Ets2
The mechanisms involved in epithelium-stroma interactions remain poorly understood, despite the importance of the microenvironment during tumorigenesis. Here, we studied the role of the Ets2 transcription factor in tumor-associated fibroblasts in the MMTV-PyMT mammary tumor model. Inactivation of ...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-16989 | biostudies-arrayexpress
ProteomicsAnimal-free three-dimensional in vitro angiogenesis tool
All metabolically active tissues have a dense vascular network to supply oxygen and nutrients. Angiogenesis, the formation of new blood vessels from existing ones, can be activated by the lack of oxygen in cells, disease, trauma, or tumor growth. Due to its essential role in cell survival, angiogene...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD077881 | Pride
Human Capillary-like formation In vitro 3d cell model Animal-free Angiogenesis Nanofibrillated cellulose hydrogel Coculture 
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