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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
TranscriptomicsExpression data from breast cancer tumor-initiating cells
We have generated tumorigenic (S2N) and non-tumorigenic (S2), normal-like to basal-like breast cancer cell lines from primary tumors. At high in vivo inoculation cell numbers of 10^6 cells/mouse both S2N and S2 monolayer as well as sphere culture cells grew at similar rates. However, at low inoculat...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-32526 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumor-initiating cells
Using a syngeneic p53 null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified by limiting dilution transplantation as well as in vitro mammosphere and clonogenic assays a Lin-CD29HighCD24High subpopulation of tumor-initiating cells. Differentially expressed ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8863 | biostudies-arrayexpress
TranscriptomicsGrowth inhibition of ovarian tumor-initiating cells by niclosamide
The gene expression profile in treated CP70 side population spheroid cells (CP70sps cells) was analyzed to investigate the effect of niclosamide inhibition on ovarian tumor-initiating cells. CP70sps cells are isolated and characterized as one kind of ovarian tumor-initiating cells, and they show ste...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36259 | biostudies-arrayexpress
TranscriptomicsTargeting Unique Metabolic Properties of Breast Tumor Initiating Cells
Bulk cancer cell populations are known to display distinct metabolic properties compared to their normal counterparts. However, relatively little is known about heterogeneity of metabolic properties within tumors. In this study we show that, analogous to some normal stem cells, breast tumor initiati...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-41286 | biostudies-arrayexpress
TranscriptomicsBrain tumor initiating cell response to microglia
Determination of the mechanism by which microglia regulate growth of brain tumor initiating cells (BTICs) and differentiation. Results identify the factors involved in the regulation and provide mechanistic basis. We subjected brain tumor initiating cells to microarray to determine the genes involve...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-52127 | biostudies-arrayexpress
ProteomicsFunctional states in tumor-initiating cell differentiation in human colorectal cancer
Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell mRNA-sequencing (scRNA-seq) of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. C...
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD018230 | Pride
Tumor heterogeneity Transcriptional programs Colorectal cancer Tumor cell differentiation Patient-derived cancer models Tumor-initiating cells Tumor metabolism Single-cell rna-sequencing 
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