Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of rat ovary in culture reveals interactions between progesterone and tumor necrosis factor-alpha in the regulation of primordial follicle assembly
Follicle assembly is the process by which groups or ‘nests’ of oocytes break down to form primordial follicles. The size of the primordial follicle pool is the major determinant of the reproductive lifespan of a female. Previously, progesterone (P4) has been shown to inhibit follicle assembly,...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8238 | biostudies-arrayexpress
ProteomicsTumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks Nuclear Factor-κB activation in hepatocellular carcinoma
Background: Tumor necrosis factor α-induced protein 1 (TNFAIP1) is frequently downregulated in cancer cell lines and promotes cancer cell apoptosis. However, its role, clinical significance and molecular mechanisms in hepatocellular carcinoma (HCC) are unknown. Methods: The expression of TNFAIP1 in...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD016378 | Pride
Protein kinase casein kinase ii beta Hepatocellular carcinoma Nuclear factor-κb Tumor suppressor Tumor necrosis factor α-induced protein 1 
TranscriptomicsHPV16 E7 expression effect on expression profile mediated by tumor necrosis factor
Acute expression of E7 oncogene from HPV-16 or HPV-18 is sufficient to overcome tumor necrosis factor-alfa (TNF) cytostatic effect on primary human keratinocytes. In the present study we investigated the molecular basis of E7-induced TNF resistance through a comparative analysis of the effect of thi...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17892 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of siRNA transfected HEK293T cells untreated or treated with TNF-alpha to study the effect of siRNA-mediated knockdown of different genes
HEK293T cells were treated with TNF-alpha for different periods of time to study the effect of siRNA-mediated knockdown of different genes (negative control: Renilla luciferase; positive controls: TNFRSF1A, RelA; gene of interest: CASP4) on TNF-induced gene expression
ORGANISM(S): Homo sapiens 
2012-07-06 | E-MTAB-900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary foreskin fibroblasts treated with tumor necrosis factor alpha
Treatment of primary human foreskin fibroblasts with tumor necrosis factor alpha
ORGANISM(S): Homo sapiens 
2009-09-01 | E-MEXP-2186 | biostudies-arrayexpress
ProteomicsIntegrated proteomic analysis of Tumor Necrosis Factor α and Interleukin 1 β-induced endothelial inflammation
Objective The vascular endothelium provides a unique interaction plane for plasma proteins and leukocytes in inflammation. It has been established that particular proteins, including ICAM1, VCAM1 and SELE, are upregulated on the endothelial cell surface in the presence of pro-inflammatory cytokines ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD009174 | Pride
Proteomics Inflammation Time-resolved Il-1β Phosphoproteomics Cell surface proteomics Endothelium Tnfα 
TranscriptomicsTranscription profiling of human umbilicial vein endothelial cells after TNF-alpha treatment
The many steps involved in the production of a mature mammalian mRNA are extensively coupled, and levels of both precursors and products can be measured using expression and genomic tiling microarrays. Different probes in these arrays targeting the same transcript often give different signals; then...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-9055 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Patients with a Variation in the TNF-alpha gene and suffering from Multiple Trauma
BACKGROUND: Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We undertook a prospective cohort study of trauma patients to examine the role of tumor...
ORGANISM(S): Homo sapiens 
2007-08-22 | E-GEOD-5760 | biostudies-arrayexpress
GenomicsCharacterizing the profiles of histone markers in mouse adipocytes during insulin resistance
Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is k...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-58491 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis reveals endogenous aryl hydrocarbon receptor regulation is highly associated with eicosanoid synthesis and tumor necrosis factor activity in MCF-7 cancer cells
Background: The Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is activated by xenobiotic chemicals that function as AHR ligands. The response to xenobiotic AHR ligands is toxicity and the induction of drug metabolizing enzymes. The impact of AHR knockdown on gene e...
ORGANISM(S): Homo sapiens 
2014-06-20 | E-GEOD-52036 | biostudies-arrayexpress
Sort   by:  
 Page size