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MetabolomicsCombined transcriptome and metabolome analysis reveals the regulatory network of histidine kinase QseC in the two-component system of Glaesserella parasuis
Glaesserella parasuis is the causative agent of Glässer's disease in pigs, which can lead to polyserositis, arthritis, and meningitis. This study used transcriptome and metabolomics sequencing techniques to investigate the mechanism of action of qseC gene in Glaesserella parasuis. Transmission elect...
2025-08-11 | MTBLS12504 | MetaboLights
TranscriptomicsTwo-component signal transduction systems in Streptomyces and related organisms
Two component sensor-response regulator systems (TCSs) are very common in the genomes of the Streptomyces species that have been fully sequenced to date. It has been suggested that this large number is an evolutionary response to the variable environment that Streptomyces encounter in soil. Notwiths...
ORGANISM(S): Streptomyces cattleya 
2010-06-24 | E-GEOD-13621 | biostudies-arrayexpress
MetabolomicsMetabolic Profiling of Escherichia coli-Based Cell-Free Expression Systems for Process Optimization
Biotechnology has transformed the production of various chemicals and pharmaceuticals due to its efficient and selective processes, but it is inherently limited by its use of live cells as 'biocatalysts.' Cell-free expression (CFE) systems, which use a protein lysate isolated from whole cells, have ...
2020-06-02 | MTBLS1079 | MetaboLights
TranscriptomicsAnalysis of Two Component Systems in Group B Streptococcus
Group B Streptococcus (GBS), in its transition from commensal to pathogen, will encounter diverse host environments and thus require coordinately controlling its transcriptional responses to these changes. This work was aimed at better understanding the role of two component signal transduction syst...
ORGANISM(S): Streptococcus agalactiae 
2014-06-03 | E-MTAB-2423 | biostudies-arrayexpress
TranscriptomicsMitochondrial two-component signaling systems in Candida albicans
Two-component signal transduction pathways are one of the primary means by which microorganisms respond to environmental signals. These signaling cascades originated in prokaryotes and were inherited by eukaryotes via endosymbiotic lateral gene transfer from ancestral cyanobacteria. We report here t...
ORGANISM(S): Candida albicans 
2013-07-02 | E-GEOD-45438 | biostudies-arrayexpress
TranscriptomicsAcid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation
Global transcriptional analysis of acid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation pH is a major environmental factor that regulates gene expression in many bacteria. Streptococcus mutans in dental biofilms is regularly exposed to cycles of a...
ORGANISM(S): Streptococcus mutans 
2010-05-22 | E-GEOD-15125 | biostudies-arrayexpress
GenomicsTwo-component signal transduction systems in Streptomyces and related organisms
Two-component signal transduction systems in Streptomyces and related organisms
PRJNA110647 | ENA
Proteomicso The CutRS two-component system controls the Streptomyces secretion stress response by monitoring extracellular disulphide bond formation
o Translocating unfolded proteins across cell membranes is essential in all domains of life and requires the conserved Sec machinery. In bacteria, Sec substrates fold on the extracellular face of the cytoplasmic membrane and misfolding triggers a stress response that involves production of HtrA-fami...
ORGANISM(S): Streptomyces venezuelae 
2025-08-09 | PXD051851 | Pride
Proteomics Two component systems Cutrs Streptomyces Secretion stress Regulation 
GenomicsValidated transcriptional regulatory roles for five two-component systems in E. coli (RNA-seq dataset)
Validated transcriptional regulatory roles for five two-component systems in E. coli (RNA-seq dataset)
PRJNA601909 | ENA
GenomicsValidated transcriptional regulatory roles for five two-component systems in E. coli (ChIP-exo dataset)
Validated transcriptional regulatory roles for five two-component systems in E. coli (ChIP-exo dataset)
PRJNA601898 | ENA
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