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ProteomicsEASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification
We developed EASI-tag (Easily Abstractable Sulfoxide-based Isobaric tag), a new generation of amine-derivatizing and sulfoxide-containing isobaric labelling reagents, which dissociate at low collision energy and generate peptide-coupled, interference-free reporter ions with high yield. Efficient iso...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2018-06-21 | PXD007165 | Pride
Isobaric labeling Proteomics Mass spectrometry 
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
TranscriptomicsExpression Data from HNF4a RNAi Knockdown in HepG2 cells
HNF4a is an important liver transcription factor that regulates at least a thousand genes in the liver. Here we used expression profiling in HepG2 cells, a hepatocellular carcinoma cell line, in which HNF4a was knocked down by RNAi to identify some of those target genes. This dataset accompanies the...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-29084 | biostudies-arrayexpress
TranscriptomicsThe impact of RNAi on the Saccharomyces castellii transcriptome
RNAi, a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model budding yeast, Saccharomyces cerevisiae. We report that RNAi is present in other budding-yeast species, including Saccharomyces castellii and Candida albicans. ...
ORGANISM(S): Naumovozyma castellii 
2009-09-10 | E-GEOD-17870 | biostudies-arrayexpress
ProteomicsInterBatch Benchmarking Experiment for Isobaric Proteomics
We developed a unique multi-batch benchmarking dataset. The design is based on a standard two-species dilution model3,18,19 with mouse plasma used to create a background of potentially interfering peptides at 1:1 ratios while yeast cultures are mixed across a range of known ratios. For the purpose...
ORGANISM(S): Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) 
2024-03-18 | PXD036799 | Pride
Isobaric Yeast Two-species interference model Mouse Tmt 
UnknownReproductive interference hampers species coexistence despite conspecific sperm precedence.
Not available
S-EPMC7920778 | biostudies-literature
UnknownHow to be proactive about interference: lessons from animal memory.
Not available
S-EPMC4670779 | biostudies-literature
UnknownModeling the Effects of Elevated Temperature and Weed Interference on Rice Grain Yield.
Not available
S-EPMC8330814 | biostudies-literature
UnknownSymbiont-mediated RNA interference in insects.
Not available
S-EPMC4810840 | biostudies-literature
TranscriptomicsGenome-scale RNAi profiling of cell division in human tissue culture cells
Cell division is a fundamental process for multicellula organisation. Here we report a genome-scale RNAi screen in HeLa cells designed to identify human genes important for cell division. We utilized a library of endoribonuclease-prepared siRNAs (esiRNAs) for gene-silencing and used DNA content an...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9176 | biostudies-arrayexpress
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