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GenomicsExpression data from Txnrd2 deficient mouse gastrocnemius muscle
Expression data from Txnrd2 deficient mouse gastrocnemius muscle
PRJNA1366462 | ENA
TranscriptomicsExpression data from Txnrd2 deficient mouse gastrocnemius muscle
TXNRD2, encoded by Txnrd2, is a mitochondrial enzyme of the pyridine nucleotide–disulfide oxidoreductase family and a key component of the thioredoxin system, essential for maintaining redox homeostasis. Because skeletal muscle is highly metabolically active and depends on efficient mitochondrial fu...
ORGANISM(S): Mus musculus 
2026-05-14 | GSE310521 | GEO
UnknownThioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
Not available
S-EPMC4207928 | biostudies-literature
UnknownCase report and literature review: novel TXNRD2 compound heterozygous variants in familial glucocorticoid deficiency type 5.
Not available
S-EPMC12301317 | biostudies-literature
UnknownLipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.
Not available
S-EPMC9772058 | biostudies-literature
UnknownGenome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
Not available
S-EPMC4731307 | biostudies-literature
UnknownLack of Association Between Polymorphisms in TXNRD2 and LMX1B and Primary Open-Angle Glaucoma in a Saudi Cohort.
Not available
S-EPMC8365832 | biostudies-literature
ProteomicsProtein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis
Cystine-xCT transporter-Glutathione (GSH)-GPX4 axis is the canonical pathway to protect against ferroptosis. While not required for ferroptosis-inducing compounds (FINs) targeting GPX4, FINs targeting the xCT transporter require mitochondria and its lipid peroxidation to trigger ferroptosis. However...
ORGANISM(S): Homo sapiens (Human) 
2025-07-05 | PXD062566 | Pride
Proteomics Coa Txnrd2 
UnknownElevated serum levels of GPX4, NDUFS4, PRDX5, and TXNRD2 as predictive biomarkers for castration resistance in prostate cancer patients: an exploratory study.
Not available
S-EPMC11920399 | biostudies-literature
UnknownMitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells.
Not available
S-EPMC5436048 | biostudies-literature
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