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ProteomicsProtein S-nitrosylation in lung endothelial cells from mouse
Long.term consequences of loss of arginase-1 (Arg1) in red blood cells were analysed by redox-proteomics. We enriched S-Nitrosylated proteins to study nitrosylated proteins in red-bood cells using a BIAM-switch assay.
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD075167 | Pride
S-nitrosylation Redox-proteomics 
ProteomicsPalm oil-rich diet affects murine liver proteome and S-palmitoylome
Palmitic acid (C16:0) is the most abundant saturated fatty acid in animals serving as a substrate in lipid synthesis and β-oxidation, and in the modification of proteins called palmitoylation. The influence of dietary palmitic acid on protein palmitoylation in the context of metabolic processes rema...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-14 | PXD025935 | Pride
S-palmitoylation Neutrophil degranulation Mass spectrometry High-fat diet Palm oil Calfacilitin/tlcd1 
ProteomicsA sensitive S-trap-based approach to the analysis of T-cell raft proteome
The development of sensitive technologies for T cell-raft proteomics is highly challenging. We explored an innovative strategy, based on suspension trapping (S-trap) sample preparation. Mouse splenocytes were subjected to negative immunoselection for T cell preparation. Rafts were isolated by a dete...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-13 | PXD016476 | Pride
T cell Optiprep Raftomics Fasp S-trap Detergent-free 
ProteomicsAbberant Cathepsin S Activity Modulates the Immune Microenvironment in Follicular Lymphoma
Tumor cells can induce their own advantageous microenvironment. Here, we describe aberrant cathepsin S (CTSS) activity to modulate T-cell activation in follicular lymphoma (FL). In donor-derived FLs following bone marrow transplantation, we identified independent acquisition of CTSS mutations at Y13...
ORGANISM(S): Homo sapiens (Human) 
2021-01-07 | PXD014612 | Pride
Cysteine-protease Hotspot mutations Immune signaling Hematology Follicular lymphoma 
ProteomicsStaphylococcus aureus isolates from the gut and the blood are ‘separated’ by host barrier integrity
The opportunistic pathogen Staphylococcus aureus is carried asymptomatically by about one-third of the human population. Body sites known to be colonized by S. aureus are the skin, nasopharynx and gut. In particular, the mechanisms that allow S. aureus to pass the gut epithelial barrier and to invad...
ORGANISM(S): Staphylococcus aureus 
2023-03-11 | PXD030971 | Pride
S. aureus  gut colonization  bacteremia  wgs  proteome  barrier 
ProteomicsElucidation of the role of murine lncRNA LL35 in hepatocytes by LC-MSMS
Long non-coding RNAs (lncRNAs) play important roles in the regulation of many biological processes in the cell like transcription, translation, splicing, transport, etc. More than 10K lncRNAs are predicted in human, but functions for the majority remain unknown. LncRNAs may contribute to the develop...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD033910 | Pride
Lc-msms Murine lncrna ll35 Aml12 cells 
ProteomicsProteomic maps of breast cancer subtypes
Systems-wide profiling of breast cancer has so far built on RNA and DNA analysis by microarray and sequencing techniques. Dramatic developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analyzed 40 estrogen ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-05 | PXD002619 | Pride
Classification Shotgun proteomics Breast cancer subtypes 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 7B; S. fermentans CBS7830 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044719 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 7A S. fermentans CBS7830 Vegetative growth
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044693 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation 5B; S. capsularis CBS5638 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044772 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
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