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ProteomicsHDL Proteomics in Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
Atherosclerotic cardiovascular disease (CVD) is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Alterations in the HDL proteome associate with prevalent CVD in T1DM. We therefore determined which proteins carried by HDL might predict incident CVD in T1DM patients. Using ta...
ORGANISM(S): Homo Sapiens 
2022-04-19 | PXD031854 | panorama
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080848 | MassIVE
ProteomicsProteomics of high density lipoprotein subfractions in type 1 diabetes mellitus and controls
Toyoshima MTK. Proteomics and functionality of high-density lipoprotein subfractions and subclinical cardiovascular disease in type 1 diabetes mellitus. Faculdade de Medicina, Universidade de Sao Paulo 2021.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-13 | MSV000087986 | MassIVE
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-20 | PXD002214 | Pride
Type 2 diabetes artery proteomics 
ProteomicsSerum Alpha-2-Macroglobulin Links Type 1 Diabetes Status and Incident Cardiovascular Disease
Background: Cardiovascular disease (CVD) is a leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM), with conventional risk factors not fully explaining the heightened risk. Study Design: We conducted a cross-sectional study comparing serum protein levels in 134 participants...
ORGANISM(S): Homo Sapiens 
2025-02-11 | PXD054039 | panorama
ProteomicsHuman Lower extremity arteries LC-MS
To explore potential therapeutic targets for diabetic vascular complications, we first conducted an unbiased screen at the protein level with lower extremity vessels from non-diabetic control individuals and from patients with type 2 diabetes by LC-MS/MS (liquid chromatography-tandem mass spectrome...
ORGANISM(S): Homo sapiens (Human) 
2025-09-05 | PXD067778 | Pride
Diabetes human vascular 
ProteomicsCatechol-modified protein extracts from human heart mitochondria after APBA chromatography
Catecholamine metabolism via monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are unclear. MAO deaminates norepinephrine (NE) and dopamine (DA) to produce H2O2 and highly reactive ‘catecholaldehydes,’ which may be toxic ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD021759 | Pride
Mitochondrial proteomics Atrial mitocardium Mao Type 2 diabetes Catecholamine metabolism Atrial tissue Human Cardiomyopathy 
ProteomicsIdentification of SEC61B as a novel regulator of calcium flux and platelet hyperactivity in diabetes mellitus
Platelet hyperactivity contributes to increased cardiovascular thrombosis in diabetes. Intracellular and released proteins control platelet activity however there are limited proteomic studies of the diabetic platelet. We isolated platelets from 34 patients without, and 42 patients with type 2 diabe...
ORGANISM(S): Homo sapiens (Human) 
2025-04-19 | PXD049321 | Pride
Sec61b Calcium Er stress Diabetes Translocon Platelet 
ProteomicsThe Pathogenic Role of Novel Anti-malondialdehyde Modified-peptide Adduct Autoantibodies in Plasma and Importing Machine Learning for Predicting Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus
The goals of this study will valid and investigate levels of MDA, MDA-modified protein, and MDA-modified peptide adducts and their autoantibody isotypes.
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD046723 | Pride
Coronary artery stenosis Plasma Coronary artery disease in patients with type 2 diabetes mellitus Malondialdehyde Autoantibody isotypes 
UnknownUrinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria.
Not available
S-EPMC5889591 | biostudies-literature
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