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TranscriptomicsReceptors are affected by selection with each Bacillus thuringiensis israelensis Cry toxin but not with the full Bti mixture in Aedes aegypti
Bacillus thuringiensis israelensis (Bti) toxins are increasingly used for mosquito control, but little is known about the precise mode of action of each of these toxins, and how they interact to kill mosquito larvae. By using RNA sequencing, we investigated change in gene transcription level and pol...
ORGANISM(S): Aedes aegypti 
2019-05-16 | E-MTAB-7970 | biostudies-arrayexpress
TranscriptomicsRNA-seq for identifying toxin MazF and MqsR cleavage sites in toxin expression and subsequent recovery cultures of Escherichia coli (mRNA and ncRNA excluding rRNA)
Bacterial toxin-antitoxin systems are thought to help bacteria to reduce their metabolism in various stressful conditions. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been mostly viewed as degraders of mRNA, however recently it was demonstrated that they ...
ORGANISM(S): Escherichia coli K-12 
2018-10-11 | E-MTAB-6993 | biostudies-arrayexpress
ProteomicsStaphylococcus aureus toxin-antitoxin system
Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. They express toxic peptides whose overexpression leads to growth arrest or cell death, whereas antitoxins regulate the expression of toxins, acting as labile antisense RNAs. The Staphylococcus aureus (S. aureus)...
ORGANISM(S): Staphylococcus aureus 
2021-07-05 | PXD023449 | Pride
S. aureus  toxin-antitoxin system  proteomics  cell death 
TranscriptomicsTranscription profiling of human cells treated with Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers
We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours Experiment Overall Design: Three experimental conditions with two biological replicates for the control condition corresponding to untreated HUVEC monolayer. RNA were extr...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-GEOD-12131 | biostudies-arrayexpress
GenomicsHigh-throughput suppressor selection of a type I toxin-antitoxin system in Helicobacter pylori
High-throughput suppressor selection of a type I toxin-antitoxin system in Helicobacter pylori
PRJNA497299 | ENA
TranscriptomicsM. smegmatis vapBC::aphA-3 M-NM-^TvapBC mutant (JR121) harboring tetracycline inducible vector pMind containing the vapBC operon (pJR230) and the pMind vector containing the vapC toxin gene (pJR29)
Transcriptional profiling of M. smegmatis JR121 expressing VapC and VapBC grown in flasks on Hartmans de Bont medium supplemented with 0.2% glycerol Comparing transcriptional response of strain JR121 to conditional expression of VapC toxin compared with the expression of VapBC complex. Biological re...
ORGANISM(S): Mycobacterium smegmatis 
2012-06-14 | E-GEOD-29631 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes reveals leukotriene D4 induces gene expression through cysteinyl leukotriene type I receptor.
Background: Cysteinyl leukotrienes (cysLTs) are important mediators of innate immune responsiveness and chronic inflammatory diseases. CysLTs acting through cysteinyl leukotriene receptors may influence the migration and activity of cells such as eosinophils, monocytes and dendritic cells. Objective...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7807 | biostudies-arrayexpress
TranscriptomicsToxin-antitoxin of Rickettsia determines fatal addiction of the host cells
Rickettsia spp. can cause mild to severe human disease. These intracellular bacteria are associated with arthropods, nematodes and trematodes, and usually, are efficiently transmitted transovarially to the progeny of the invertebrate host. We recently demonstrated foreign gene acquisition by lateral...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-22072 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to identify novel genes regulated by Cholera toxin in bone marrow-derived dendritic cells (BMDCs)
The mechanisms by which dendritic cells (DCs) induce differentiation of naïve CD4+ T cells along the Th2 lineage is not well understood given that DCs themselves do not produce IL-4. In the present study, we undertook a microarray approach to identify genes involved in the induction of Th2 differe...
ORGANISM(S): Mus musculus 
2008-04-14 | E-GEOD-10815 | biostudies-arrayexpress
TranscriptomicsGenetic homogeneity among strains of Clostridium botulinum type A1 with a unique toxin gene cluster organization
Comparative genomic hybridizations were performed to compare bont/A1 strains with an A2-like toxin gene cluster organization to the genome sequenced strain, C. botulinum ATCC 3502. Keywords: comparative genomic hybridization For each hybridization, the reference strain (C. botulinum ATCC 3502) was...
ORGANISM(S): Clostridium botulinum 
2010-05-26 | E-GEOD-10223 | biostudies-arrayexpress
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