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ProteomicsProteomic changes induced by knockdown of UBE2D/eff in adult fly musccle
The project goal is to identify the Proteomic changes induced by knockdown of UBE2D/eff in adult fly musccle.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-11-14 | PXD042345 | Pride
Ube2d  eff  ubiquitin  drosophila 
TranscriptomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Ubiquitin (Ub) is a protein post-translational modification that controls proteostasis through mechanisms spanning transcription, translation, and protein degradation. Ub conjugation occurs through a cascade of three enzyme classes (E1, E2, and E3s) involving >1000 proteins that regulate the ubiquit...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE298221 | GEO
GenomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Designed, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
PRJNA1268535 | ENA
ProteomicsUBOX-UBL versus UBOX-UBLcontrol tranfected into HeLa Cells
In this work, we developed a suite of linked-domain UBE2D inhibitors. We transfected these constructs into HeLa cells and used shotgun proteomics with label-free quantification to measure which protein's abundances are affected by UBE2D inhibition.
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD040264 | Pride
Ube2d E2 Ubiquitin 
UnknownNEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Not available
S-EPMC7050210 | biostudies-literature
UnknownDesign of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination.
Not available
S-EPMC11398408 | biostudies-literature
UnknownThe ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging.
Not available
S-EPMC10759998 | biostudies-literature
UnknownThe UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution.
Not available
S-EPMC9790923 | biostudies-literature
UnknownThe ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity.
Not available
S-EPMC11778781 | biostudies-literature
ProteomicsUD1long pulldown from HeLa Cell Extract
Here we used a his-tagged version of the UD1long UBE2D inhibitor to pulldown protein from HeLa cell extract
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD065412 | Pride
Ube2d Ubiquitin Linked-domain inhibitors 
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